Transfused blood contains lower levels of 2,3-DPG

the verdict

SUPPORTED

the evidence backs this

Recorded sources

2 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Transfused blood contains lower levels of 2,3-DPG?

Yes. Transfused blood typically exhibits lower levels of 2,3-DPG due to the depletion of this metabolite during the standard storage period of red blood cells.

Verdict: SUPPORTED · 2 sources for, 0 against · Last checked 4 Aug 2026

The analysis

The claim is specific and empirical, addressing the biochemical changes in stored blood products (the red blood cell storage lesion). The retrieved literature, specifically papers [0] and [8], directly confirms that red blood cells experience a depletion or lower level of 2,3-DPG during storage prior to transfusion. Therefore, the claim is supported by the evidence.

Evidence for · 2

Perfusion vs. oxygen delivery in transfusion with “fresh” and “old” red blood cells: The experimental evidence

2010

This paper discusses red blood cell storage and notes that 2,3-DPG depletion occurs during storage, leading to increased oxygen affinity in stored red blood cells.

Get citation

Tsai, A., Hofmann, A., Cabrales, P., & Intaglietta, M. (2010). Perfusion vs. oxygen delivery in transfusion with “fresh” and “old” red blood cells: The experimental evidence. doi.org. https://doi.org/10.1016/j.transci.2010.05.011

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More for · 1

The expression of CD47 and its association with 2,3-DPG levels in stored leuco-reduced blood units.

2019

This study demonstrates that stored red blood cells experience a significant decrease in 2,3-DPG levels over time as part of the red cell storage lesion.

Get citation

Eldesouky, N. A., Fetouh, R. M. A. E., Hafez, A. A., Gad, A., & Kamal, M. M. (2019). The expression of CD47 and its association with 2,3-DPG levels in stored leuco-reduced blood units.. doi.org. https://doi.org/10.1016/j.tracli.2019.01.004

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Receipt History

first checked04 Aug 2026

judged → SUPPORTED · 8804 Aug 2026

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