Ibuprofen use causes miscarriage

the verdict

SUPPORTED

the evidence backs this

Recorded sources

2 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that ibuprofen use causes miscarriage?

Yes. Multiple large cohort and registry studies indicate that the use of ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) during early pregnancy is significantly associated with an increased risk of miscarriage or spontaneous abortion.

Verdict: SUPPORTED · 2 sources for, 0 against · Last checked 5 Aug 2026

The analysis

Papers [0] and [2] directly investigate the relationship between ibuprofen/NSAID use during pregnancy and spontaneous abortion/miscarriage, concluding that there is a statistically significant positive association. No provided papers refute this relationship.

Evidence for · 2

Use of nonaspirin nonsteroidal anti-inflammatory drugs during pregnancy and the risk of spontaneous abortion

2011

Evaluated prescription NSAID use in pregnancy and found that ibuprofen use was significantly associated with an increased risk of spontaneous abortion.

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nakhai-Pour, H. R., Broy, P., Sheehy, O., & Bérard, A. (2011). Use of nonaspirin nonsteroidal anti-inflammatory drugs during pregnancy and the risk of spontaneous abortion. doi.org. https://doi.org/10.1503/cmaj.110454

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More for · 1

Use of nonsteroidal antiinflammatory drugs during pregnancy and the risk of miscarriage

2018

Examined nonsteroidal antiinflammatory drug use in early pregnancy and found an increased risk of miscarriage associated with use around conception.

Get citation

Li, D., Ferber, J., Odouli, R., & Quesenberry, C. (2018). Use of nonsteroidal antiinflammatory drugs during pregnancy and the risk of miscarriage. doi.org. https://doi.org/10.1016/j.ajog.2018.06.002

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Is it true that drinking alcohol during pregnancy increases the risk of miscarriage? SUPPORTED related question, same topic
Is it true that Amniocentesis carries a measurable risk of miscarriage? SUPPORTED related question, same topic
Is it true that night shift work during pregnancy increases the risk of miscarriage? SUPPORTED related question, same topic

also asked as

Does taking ibuprofen lead to miscarriage?
Is it true that ibuprofen causes miscarriage?
Can using ibuprofen result in a miscarriage?
Are miscarriages caused by ibuprofen use?

Receipt History

first checked05 Aug 2026

judged → SUPPORTED · 7705 Aug 2026

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