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the claim
Ibuprofen reduces fever in adults.
the verdict
INSUFFICIENT LEANING
Recorded sources
8 sources for · 1 against
Is it true that ibuprofen reduces fever in adults?
Unclear. Several sources indicate ibuprofen reduces fever in adults, including a meta-analysis of IV ibuprofen in postoperative adults and a placebo-controlled trial in hospitalized adults, but each covers only a narrow population or route rather than the general claim.
Verdict: PARTIAL LEAN · 8 sources for, 1 against · Last checked
Evidence for · 8
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Ibuprofen. (n.d.). en.wikipedia.org. https://en.wikipedia.org/wiki/Ibuprofen
Evidence against · 1
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LORIN, M. I. (1991). Ibuprofen for Fever. doi.org. https://doi.org/10.1542/peds.87.1.125a
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More for · 7
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Krudsood, S., Tangpukdee, N., Wilairatana, P., Pothipak, N., Duangdee, C., Warrell, D. A., & Looareesuwan, S. (2010). Intravenous Ibuprofen (IV-ibuprofen) Controls Fever Effectively in Adults with Acute Uncomplicated Plasmodium falciparum Malaria but Prolongs Parasitemia. doi.org. https://doi.org/10.4269/ajtmh.2010.09-0621
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Zhou, P., Chen, L., Wang, E., He, L., Tian, S., & Zhai, S. (2023). Intravenous Ibuprofen in Postoperative Pain and Fever Management in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials. doi.org. https://doi.org/10.22541/au.168017949.92841320/v1
The use of ibuprofen to treat fever in COVID-19: A possible indirect association with worse outcome?
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Jamerson, B. & Haryadi, T. H. (2020). The use of ibuprofen to treat fever in COVID-19: A possible indirect association with worse outcome?. doi.org. https://doi.org/10.1016/j.mehy.2020.109880
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A multi-center, randomized, double-blind, parallel, placebo-controlled trial to evaluate the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for the treatment of fever in critically ill and non-critically ill adults. (n.d.). cir.nii.ac.jp. https://doi.org/10.1186/cc9089
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Antipyretic Use in Noncritically Ill Patients With Fever: A Review - PMC Lock. (n.d.). pmc.ncbi.nlm.nih.gov. https://doi.org/10.7759/cureus.51943
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Ibuprofen vs. Acetaminophen: What’s the Difference?. (n.d.). health.clevelandclinic.org. https://health.clevelandclinic.org/acetaminophen-vs-ibuprofen-which-works-better
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Gan, T. J., Gibson, B., Durr, E., Abad, A., Zaborny, B., Bergese, S., & Southworth, S. (2025). The Safety and Efficacy of Intravenous Ibuprofen in Older Patients: A Retrospective Subgroup Analysis.. doi.org. https://doi.org/10.1016/j.clinthera.2025.04.021
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