Amniocentesis carries a measurable risk of miscarriage
the verdict
SUPPORTED
the evidence backs this
confidence 92/100
Current systematic reviews and meta-analyses indicate that amniocentesis carries a measurable risk of miscarriage, though modern estimates (generally under 1%) are considerably lower than historical figures.
Evidence for · 4
Procedure‐related risk of miscarriage following amniocentesis and chorionic villus sampling: a systematic review and meta‐analysis
2015 · cited by 583
A systematic review and meta-analysis estimated the overall risk of miscarriage prior to 24 weeks following amniocentesis at 0.81%.
See more details
More for · 3
Risk of miscarriage following amniocentesis or chorionic villus sampling: systematic review of literature and updated meta‐analysis
2019 · cited by 305
An updated systematic review and meta-analysis confirmed that amniocentesis carries a measurable, though historically overestimated, risk of procedure-related complications.
Procedure‐related risk of miscarriage following chorionic villus sampling and amniocentesis
2019 · cited by 54
A large retrospective cohort study found an amniocentesis miscarriage rate of 0.8%, though noting it was not statistically different from unexposed control groups.
Difference in Procedure-Related Risk of Miscarriage between Early and Mid-Trimester Amniocentesis: A Retrospective Cohort Study
2021 · cited by 9
A comparative cohort study evaluating early versus mid-trimester amniocentesis reported procedure-related fetal loss rates ranging between 0.36% and 0.82%.