The claim that the brain cannot adapt to low dopamine levels is refuted by extensive neuroplasticity research demonstrating that reward circuitry and neural pathways undergo significant structural and functional adaptations in response to dopamine depletion.
The claim asserts a biological impossibility regarding neuroadaptation. Multiple retrieved papers document how dopamine depletion or receptor downregulation triggers neural plasticity, maladaptive changes, or compensatory mechanisms (such as D2 receptor downregulation from poor diet, lesion-induced behavioral adaptations in songbirds, and mesolimbic pathway adjustments). Therefore, the claim is clearly contradicted by the evidence.