Neurons maintain a negative resting potential due to ion concentration gradients and permeability

the verdict

SUPPORTED

the evidence backs this

Recorded sources

3 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that neurons maintain a negative resting potential due to ion concentration gradients and permeability?

Yes. Multiple studies demonstrate that neurons and other excitable cells maintain their negative resting membrane potential through established ion concentration gradients and selective membrane permeability.

Verdict: SUPPORTED · 3 sources for, 0 against · Last checked 5 Aug 2026

The analysis

The claim is specific, empirical, and falsifiable. Papers [1], [6], and [10] directly support the physiological principles that ion concentration gradients (such as potassium and sodium) and membrane permeability govern the resting membrane potential. No papers refute this well-established consensus in neurophysiology.

Evidence for · 3

Sodium and potassium fluxes and membrane potential of human neutrophils: evidence for an electrogenic sodium pump

1982

Demonstrates that resting membrane potential and ion fluxes in cells depend on sodium and potassium concentrations and permeability.

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Simchowitz, L., Spilberg, I., & Weer, P. (1982). Sodium and potassium fluxes and membrane potential of human neutrophils: evidence for an electrogenic sodium pump. doi.org. https://doi.org/10.1085/jgp.79.3.453

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More for · 2

The Effect of Calcium Ions on Resting Membrane Potential

2024

Illustrates how ion distributions and movements, such as potassium leak channels and calcium/sodium dynamics, establish and modulate the resting membrane potential.

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Elliott, E. R. & Cooper, R. (2024). The Effect of Calcium Ions on Resting Membrane Potential. doi.org. https://doi.org/10.3390/biology13090750

Activity-Dependent Fluctuations in Interstitial [K+]: Investigations Using Ion-Sensitive Microelectrodes

2023

Shows that neuronal resting membrane potential is maintained and restored via potassium ion concentration gradients and efflux.

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Beswick-Jones, H., Hopper, A. J., & Brown, A. M. (2023). Activity-Dependent Fluctuations in Interstitial [K+]: Investigations Using Ion-Sensitive Microelectrodes. doi.org. https://doi.org/10.3390/molecules28020523

Related receipts

Is it true that resting potentials and action potential thresholds are uniform across all neurons in a network? REFUTED related question, same topic
Is it true that the sodium-potassium pump actively maintains cellular resting potential using ATP? SUPPORTED related question, same topic

Receipt History

first checked05 Aug 2026

judged → SUPPORTED · 8705 Aug 2026

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