A single neuron can exert both inhibitory and excitatory effects on postsynaptic targets
Multiple studies demonstrate that individual neurons can elicit distinct excitatory or inhibitory effects on different postsynaptic targets, often through the co-release of multiple neurotransmitters or target-specific receptor specialization.
The claim is specific and empirical, addressing neuronal signaling and synaptic physiology. Papers [3] and [6] provide direct evidence that individual neurons can produce different functional outcomes (exhibiting both excitatory and inhibitory responses depending on the target or receptors involved). Thus, the claim is well-supported by the provided literature.
Guillaume P Dugué, Andréa Dumoulin, Antoine Triller, Stéphane Dieudonné. Target-dependent use of co-released inhibitory transmitters at central synapses.. 2005. https://doi.org/10.1523/JNEUROSCI.1500-05.2005
The study demonstrates that a single Golgi cell can perform pure GABAergic inhibition on granule cells and pure glycinergic inhibition on unipolar brush cells, illustrating target-specific signaling of mixed inhibitory transmitters.
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W Poelchen, D Sieler, K Wirkner, P Illes. Co-transmitter function of ATP in central catecholaminergic neurons of the rat.. 2001. https://doi.org/10.1016/s0306-4522(00)00529-7
The study provides electrophysiological evidence that central neurons can co-release transmitters (ATP and catecholamines) that activate both excitatory and inhibitory receptors on target neurons.
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