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the claim

The 2014-2015 influenza vaccine had low efficacy against circulating strains

the verdict
SUPPORTED
the evidence backs this
Recorded sources
5 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Multiple studies and surveillance reports confirm that the 2014-2015 influenza vaccine exhibited low efficacy and reduced protection against circulating H3N2 strains due to significant antigenic drift and mismatch.

The analysis

The retrieved papers consistently report that the 2014-2015 influenza season featured an antigenic mismatch between circulating H3N2 strains (such as clade 3C.2a) and the vaccine strain, leading to substantially reduced vaccine effectiveness across multiple populations. Therefore, the claim is strongly supported.

Evidence for · 5
Identification of hemagglutinin residues responsible for H3N2 antigenic drift during the 2014–2015 influenza season
Recorded source metadata

Benjamin S Chambers, Kaela Parkhouse, T. Ross, K. Alby, S. Hensley. Identification of hemagglutinin residues responsible for H3N2 antigenic drift during the 2014–2015 influenza season. 2015. https://doi.org/10.1016/j.celrep.2015.06.005

Demonstrates that mutations in the hemagglutinin antigenic site B caused an antigenic mismatch, explaining the low efficacy of the 2014-2015 influenza vaccine.

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More for · 4
H3N2 Mismatch of 2014–15 Northern Hemisphere Influenza Vaccines and Head-to-head Comparison between Human and Ferret Antisera derived Antigenic Maps
Recorded source metadata

Hang Xie, X. Wan, Z. Ye, Ewan P. Plant, Yangqing Zhao, Yifei Xu, Xing Li, Courtney L. Finch, Nan Zhao, T. Kawano, O. Zoueva, Meng-Jung Chiang, Xianghong Jing, Zhengshi Lin, A. Zhang, Yanhong Zhu. H3N2 Mismatch of 2014–15 Northern Hemisphere Influenza Vaccines and Head-to-head Comparison between Human and Ferret Antisera derived Antigenic Maps. 2015. https://doi.org/10.1038/srep15279

Shows that individuals vaccinated with the 2014-2015 northern hemisphere vaccine experienced a significant reduction in antibody titers against circulating H3N2 epidemic strains.

Interim estimates of 2014/15 vaccine effectiveness against influenza A(H3N2) from Canada's Sentinel Physician Surveillance Network, January 2015.
Recorded source metadata

D. Skowronski, C. Chambers, S. Sabaiduc, G. Serres, G. Serres, James A. Dickinson, Anne‐Luise Winter, S. Drews, K. Fonseca, H. Charest, J. Gubbay, M. Petric, M. Krajden, T. L. Kwindt, C. Martineau, A. Eshaghi, N. Bastien, Yan Li, Yan Li. Interim estimates of 2014/15 vaccine effectiveness against influenza A(H3N2) from Canada's Sentinel Physician Surveillance Network, January 2015.. 2015. https://doi.org/10.2807/1560-7917.ES2015.20.4.21022

Reports that the 2014-2015 vaccine showed little to no protection against circulating A(H3N2) viruses due to substantial antigenic mismatch.

Influenza Vaccine Effectiveness Against Antigenically Drifted Influenza Higher Than Expected in Hospitalized Adults: 2014–2015
Recorded source metadata

J. Petrie, S. Ohmit, E. Martin, Ryan E. Malosh, Caroline K. Cheng, A. Lauring, L. Lamerato, Katherine C. Reyes, Heather R. Lipkovich, B. Flannery, J. Ferdinands, A. Monto. Influenza Vaccine Effectiveness Against Antigenically Drifted Influenza Higher Than Expected in Hospitalized Adults: 2014–2015. 2015. https://doi.org/10.1093/ofid/ofv130.09

Notes that the 2014-2015 season experienced widespread circulation of antigenically drifted H3N2 viruses with anticipated low vaccine effectiveness.

Influenza - the need to stay ahead of the virus.
Recorded source metadata

S. V. D. Werf, S. V. D. Werf, D. Levy-Bruhl. Influenza - the need to stay ahead of the virus.. 2015. https://doi.org/10.2807/1560-7917.ES2015.20.5.21030

Synthesizes multiple reports showing substantially reduced vaccine effectiveness during the 2014-2015 season due to antigenic mismatch.

The paper trail · every fact has a biography
first checked02 Aug 2026
judged → SUPPORTED · 9002 Aug 2026
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