Anorexia nervosa causes long-term physical damage to organ systems
Anorexia nervosa is associated with extensive physiological complications that can lead to permanent damage across multiple organ systems.
The retrieved literature consistently demonstrates that anorexia nervosa causes widespread and potentially permanent medical complications across various organ systems, including cardiovascular, renal, hepatic, endocrine, and skeletal systems. Multiple comprehensive reviews and large cohort studies support this finding without contradictory evidence.
Philip S. Mehler, Carrie Brown. Anorexia nervosa – medical complications. 2015. https://doi.org/10.1186/s40337-015-0040-8
Paper 0 establishes that anorexia nervosa adversely affects almost every body system and can cause permanent adverse sequelae.
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Leah Puckett, Daniela Grayeb, Vishnupriya Khatri, Kamila Cass, Philip S. Mehler. A Comprehensive Review of Complications and New Findings Associated with Anorexia Nervosa. 2021. https://doi.org/10.3390/jcm10122555
Paper 5 confirms that widespread physiological changes affect nearly every organ system in patients with anorexia nervosa.
Dalit Modan‐Moses, Amit Yaroslavsky, Brigitte Kochavi, Anat Toledano, Sharon Iron‐Segev, Fadel Balawi, Edith Mitrany, Dan J. Stein. Linear Growth and Final Height Characteristics in Adolescent Females with Anorexia Nervosa. 2012. https://doi.org/10.1371/journal.pone.0045504
Paper 7 identifies linear growth retardation as a prominent long-term feature in adolescent patients with anorexia nervosa.
Sandra Trapani, Chiara Rubino. Medical Complications of Anorexia Nervosa. 2025. https://doi.org/10.1542/peds.2024-070304
Paper 8 reviews the acute and chronic medical consequences of anorexia nervosa across multiple organ systems, noting life-threatening complications.
Morgan C, Carr MJ, Chew-Graham CA, O'Neill TW, Elvins R, Kapur N, Webb RT, Ashcroft DM. Adverse outcomes in patients with a diagnosis of an eating disorder: primary care cohort study with linked secondary care and mortality records.. 2025. https://doi.org/10.1136/bmjmed-2025-001438
Paper 10 demonstrates through a large cohort study that individuals with eating disorders face elevated long-term risks for conditions such as renal failure and liver disease.
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