Leucovorin rescue selectively protects normal cells without stimulating tumor growth.

the verdict

SUPPORTED

the evidence backs this

Recorded sources

2 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Leucovorin rescue selectively protects normal cells from high-dose methotrexate toxicity by restoring folate-dependent pathways without reducing the antineoplastic efficacy against tumor cells.

The analysis

The claim is a specific, well-established pharmacological principle regarding the mechanism of leucovorin rescue following high-dose methotrexate therapy. The retrieved literature directly discusses how leucovorin provides systemic protection to normal tissues while allowing high concentration-time exposures against cancer cells. Therefore, the evidence strongly supports the claim.

Evidence for · 2

The effects on 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue.

Recorded source metadata

L. Matherly, C. Barlowe, V. Phillips, I. Goldman. The effects on 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue.. 1987. https://doi.org/10.1016/s0021-9258(19)75842-6

Evaluates the biochemical basis and metabolic selectivity of leucovorin rescue in relation to antifolate treatment.

Source citation format

See more details

More for · 1

Long-duration intracavitary infusion of methotrexate with systemic leucovorin protection in patients with malignant effusions.

Recorded source metadata

Stephen B. Howell, B B Chu, W E Wung, B M Metha, John Mendelsohn. Long-duration intracavitary infusion of methotrexate with systemic leucovorin protection in patients with malignant effusions.. 1981. https://doi.org/10.1172/jci110130

Demonstrates that leucovorin administration provides systemic protection against high-dose methotrexate toxicity without diminishing the therapeutic exposure of malignant cells.

Source citation format

The paper trail · every fact has a biography

first checked02 Aug 2026

judged → SUPPORTED · 8702 Aug 2026

More receipts

Is it true that Phonological evolution involves regular processes of phoneme elision, vowel nasalization, and tonogenesis?Is it true that Hemangiomas are treatable with medication?Is it true that Research identifies forms of intelligence that diverge from standard IQ measures?

Random receipt →The Trust Wiki →

Anyone with this link can read the claim and its public receipt, including any personal information in that text. Open permanent receipt.

Check your own claim

Challenge the receipt

I have a source that contradicts this verdict I have a source that supports it No source: request a receipt review Requests are recorded for review. This does not start an automatic check or guarantee a response time.

trust me, bro: win the argument, pass the class, survive peer review.

Citation formatting by citeproc-js (Frank Bennett) and the Citation Style Language project. Source and licenses.

This receipt is an automated verdict against our published method · not an opinion about any author or publication.
Terms · Privacy · How verdicts work · Dispute this receipt