Schwann cells are the sole source of myelination in the peripheral nervous system
The retrieved papers consistently confirm that Schwann cells are the primary glial cells responsible for myelin sheath formation in the peripheral nervous system.
The provided literature consistently supports the standard neuroscientific consensus that Schwann cells are the myelinating glial cells of the peripheral nervous system (PNS). None of the papers refute this foundational premise; instead, they examine the molecular, mechanical, and genetic regulators of Schwann cell myelination.
Sophie Belin, Kristen L. Zuloaga, Y. Poitelon. Influence of Mechanical Stimuli on Schwann Cell Biology. 2017. https://doi.org/10.3389/fncel.2017.00347
States that Schwann cells are the glial cells of the peripheral nervous system that insulate axons by forming the myelin sheath.
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Fan M, Sun Y, Mei R, Lu W, Zhao X, Yang A, Qiu M. Control of Schwann Cell Myelination by DDR1 Receptor Tyrosine Kinase.. 2026. https://doi.org/10.3390/ijms27115135
Describes how immature Schwann cells differentiate into myelinating Schwann cells in the peripheral nervous system.
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