SerpinB3 plays a specific functional role in human physiological and pathological processes
Multiple studies demonstrate that SerpinB3 plays critical functional roles in both physiological and pathological processes, notably regulating oxidative stress responses, tissue protection, and cancer progression.
The claim is specific and testable regarding the biological role of SerpinB3. Numerous retrieved papers provide empirical evidence detailing its specific molecular functions in cancer, oxidative stress response, and pathological signaling. There is robust, unanimous support from the literature.
Claire Heit, Brian C. Jackson, Monica McAndrews, Matt W. Wright, David C. Thompson, Gary A. Silverman, Daniel W. Nebert, Vasilis Vasiliou. Update of the human and mouse SERPINgene superfamily. 2013. https://doi.org/10.1186/1479-7364-7-22
Highlights the serpin superfamily and notes their functional diversity across physiological and pathological processes including tumorigenesis and inflammation.
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Francesco Ciscato, Marco Sciacovelli, Gianmarco Villano, Cristian Turato, Paolo Bernardi, Andrea Rasola, Patrizia Pontisso. SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I. 2013. https://doi.org/10.18632/oncotarget.1411
Demonstrates that SERPINB3 plays a specific functional role in protecting cells from oxidative stress and chemotherapy-induced apoptosis by inhibiting mitochondrial respiratory complex I.
Margherita Correnti, A. Cappon, Mirella Pastore, Benedetta Piombanti, Giulia Lori, Douglas VNP Oliveira, Patricia Muñoz-Garrido, Monika Lewińska, Jesper B. Andersen, Cédric Coulouarn, Laurent Sulpice, Caterina Peraldo‐Neia, Giuliana Cavalloni, Santina Quarta, Alessandra Biasiolo, Matteo Fassan, Matteo Ramazzotti, Matteo Parri, Stefania Recalcati, Luca Di Tommaso, Claudia Campani, Pietro Invernizzi, Guido Torzilli, Fabio Marra, Patrizia Pontisso, Chiara Raggi. The protease‐inhibitor SerpinB3 as a critical modulator of the stem‐like subset in human cholangiocarcinoma. 2021. https://doi.org/10.1111/liv.15049
Shows that SerpinB3 acts as a critical modulator of the stem-like phenotype and malignant behavior in cholangiocarcinoma.
Stefania Cannito, Cristian Turato, Claudia Paternostro, Alessandra Biasiolo, Sebastiano Colombatto, Irene Cambieri, Santina Quarta, Erica Novo, Elisabetta Morello, Gianmarco Villano, Silvano Fasolato, Tiziana Musso, Ezio David, Ignazia Tusa, Elisabetta Rovida, Riccardo Autelli, Antonina Smedile, Umberto Cillo, Patrizia Pontisso, Maurizio Parola. Hypoxia up-regulates SERPINB3 through HIF-2α in human liver cancer cells. 2014. https://doi.org/10.18632/oncotarget.2943
Finds that hypoxia up-regulates SERPINB3 via HIF-2alpha, indicating a specific role for SERPINB3 in cancer cell responses and oncogenesis.
Cristian Turato, Alessandro Vitale, Silvano Fasolato, Mariagrazia Ruvoletto, Liliana Terrin, Santina Quarta, Rafael Morales, Alessandra Biasiolo, Giacomo Zanus, Narges Zali, Poh Seng Tan, Yujin Hoshida, A. Gatta, Umberto Cillo, Patrizia Pontisso. SERPINB3 is associated with TGF-β1 and cytoplasmic β-catenin expression in hepatocellular carcinomas with poor prognosis. 2014. https://doi.org/10.1038/bjc.2014.246
Establishes that high SERPINB3 expression correlates with aggressive molecular signatures and poor prognosis in hepatocellular carcinomas.
Cagnin S, Pontisso P, Martini A. SerpinB3: A Multifaceted Player in Health and Disease-Review and Future Perspectives.. 2024. https://doi.org/10.3390/cancers16142579
Reviews the multifaceted roles of SerpinB3, confirming its involvement in carcinogenesis, fibrosis, metabolic regulation, and tissue protection.
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