The human immune system develops new allergies over a lifetime through sensitization
Clinical and immunological studies confirm that the human immune system can become sensitized to new allergens and develop de novo allergic diseases over a lifetime.
The claim states that the immune system develops new allergies over a lifetime through sensitization. Multiple retrieved papers document adult-onset food allergies, de novo allergic syndromes, and the immunological mechanisms of sensitization in humans over time, providing strong support.
Human germline gain-of-function in STAT6: from severe allergic disease to lymphoma and beyond.. 2024. https://doi.org/10.1016/j.it.2023.12.003
Discusses how human germline variants drive severe allergic disease and how immune dysregulation informs fundamental mechanisms of allergic sensitization.
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L. K. Poulsen. In search of a new paradigm: mechanisms of sensitization and elicitation of food allergy*. 2005. https://doi.org/10.1111/j.1398-9995.2005.00821.x
Highlights research priorities into mechanisms of sensitization and the immune response to food allergens over time.
Graham Walter, Chrystyna Kalicinsky. Adult-onset IgE-mediated food allergy at a Winnipeg allergy clinic: a case series. 2020. https://doi.org/10.1186/s13223-020-00483-5
Documents clinical cases of adult-onset IgE-mediated food allergy, demonstrating that allergies can develop later in life.
P. González-Delgado, Ana Entrala, Ramon Nuñez-Orjales, E. Marchan, Javier Fernández, A. Nowak-Węgrzyn. Food protein-induced enterocolitis syndrome in adults: review and practice recommendations. 2024. https://doi.org/10.37349/eaa.2024.00036
Shows that allergic conditions like food protein-induced enterocolitis syndrome can develop de novo in adulthood.
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