Certain chemical groups can undergo self-substitution reactions
Chemical groups can indeed participate in self-substitution or intramolecular substitution reactions, as supported by well-documented mechanisms like neighboring group participation and substrate-assisted pathways.
The retrieved papers provide clear and specific evidence of self-substitution and intramolecular nucleophilic substitution reactions driven by neighboring group participation or substrate assistance. The claim is specific, empirical, and well-supported by established organic chemistry principles present in the literature.
Suresh R, Orbach N, Marek I. Stereoinvertive S<sub>N</sub>1 Through Neighboring Group Participation.. 2024. https://doi.org/10.1002/anie.202407602
Discusses neighboring group participation leading to intramolecular substitution reactions such as SN1 processes.
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Overkleeft HS, Davies GJ, Williams SJ. Catalyzing Carbohydrate Cleavage: Glycosidases and Their Mechanisms.. 2026. https://doi.org/10.1021/acs.chemrev.5c00803
Details substrate-assisted retention mechanisms involving internal group participation and substitution.
Matter ME, Devin RC, Stache EE. Photothermal Conversion Promotes Challenging S<sub>N</sub>Ar for Facile C─N Bond Formation.. 2026. https://doi.org/10.1002/anie.202522296
Examines intramolecular S_N Ar reactions where specific chemical groups undergo substitution within the same molecular framework.
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