Harmful and beneficial stress affect tendons differently
Beneficial mechanical stimuli help maintain tendon structure and function, whereas mechanical overload and harmful stress lead to adverse molecular and structural remodeling, such as decreased collagen thermal stability and fiber disorganization.
The retrieved literature includes specific experimental studies (such as papers [1] and [8]) demonstrating that harmful mechanical stress (overload or impingement) causes distinct pathological alterations in tendon collagen structure and stability, contrasting with standard physiological mechanobiology. The claim is well-supported by these findings.
Thomas L. Willett, Rosalind S. Labow, J. Michael Lee. Mechanical overload decreases the thermal stability of collagen in an in vitro tensile overload tendon model. 2008. https://doi.org/10.1002/jor.20672
Demonstrates that mechanical overload decreases the thermal stability and disrupts the collagen lattice structure of tendons, showing negative structural changes.
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Wise BC, Mora KE, Lee W, Buckley MR. Murine Hind Limb Explant Model for Studying the Mechanobiology of Achilles Tendon Impingement.. 2023. https://doi.org/10.3791/65801
Shows that mechanical impingement and altered strain environments cause adverse remodeling such as excess glycosaminoglycan deposition and collagen disorganization.
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