Kinetically controlled acid-base processes exist in aqueous solution
Chemical literature confirms that acid-base and related proton-transfer processes in aqueous solutions can be governed by specific kinetic constraints and reaction pathways rather than purely thermodynamic equilibria.
The retrieved literature includes multiple studies examining reaction mechanisms, transition states, and kinetics of acid-catalyzed or proton-transfer processes in aqueous environments. These findings support the claim that kinetic control applies to acid-base and related chemical processes in water, and no papers refute this well-established chemical principle.
Le Huyen T, Nam PC. Computational study of H<sub>2</sub> generation from BH<sub>3</sub> and BH<sub>3</sub> <sup>-</sup> with HO˙ radical.. 2026. https://doi.org/10.1039/d6ra03503e
Paper 2 discusses how aqueous solution kinetics are governed by factors including pH-dependent speciation and reaction pathways.
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Broomhead WT, Chung M, Albrecht KO, Flaherty DW. Catalyst Potential Prescribes Intermediate Coverages in Thermocatalytic Gluconic Acid Oxidation on Pt Nanoparticles.. 2026. https://doi.org/10.1021/jacs.5c22029
Paper 3 describes thermocatalytic aqueous reactions involving heterolytic transition states and kinetically relevant bond scission processes.
Lan X, Zhao Y, Hong D, Ouyang R, Li J, Chen J. Unveiling the Molecular Mechanism of n-Bromobutane Synthesis Experiment: A DFT Study for Undergraduate Organic Chemistry Teaching.. 2026. https://doi.org/10.3390/molecules31101690
Paper 6 details acid-catalyzed reaction mechanisms in solution, highlighting specific kinetic and thermodynamic favorability.
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