Molecular machinery targets recombination hotspots to cut chromosomes
Multiple studies demonstrate that specialized molecular complexes, such as PRDM9 and associated chromatin remodelers, specifically target and open recombination hotspots to facilitate chromosomal DNA cutting and meiotic recombination.
The retrieved papers consistently show that specific molecular factors (such as PRDM9, HELLS, and associated enzymatic machinery) target and open chromatin at recombination hotspots to facilitate the formation of DNA double-strand breaks during meiosis. Therefore, the claim is well-supported by current genetic and molecular evidence.
Catrina Spruce, S. Dlamini, G. Ananda, N. Bronkema, H. Tian, K. Paigen, G. Carter, Christopher L. Baker. HELLS and PRDM9 form a pioneer complex to open chromatin at meiotic recombination hot spots. 2019. https://doi.org/10.1101/gad.333542.119
HELLS and PRDM9 act as a pioneer complex that opens chromatin at recombination hotspots to permit access for the DNA double-strand break machinery.
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Zhang X, Liu Y, Wang N. Dynamic changes in histone lysine lactylation during meiosis prophase I in mouse spermatogenesis.. 2025. https://doi.org/10.1073/pnas.2418693122
Histone modifications such as H4K8la associate closely with recombination hotspots where DNA double-strand break processing machinery engages.
Reine U. Protacio, Tresor O. Mukiza, M. Davidson, W. Wahls. Molecular mechanisms for environmentally induced and evolutionarily rapid redistribution (plasticity) of meiotic recombination. 2021. https://doi.org/10.1093/genetics/iyab212
DNA site-dependent hotspots modulate rates of recombination and directly promote the activity of the basal recombination machinery including the Spo11/Rec12 complex.
Raynaud M, Sanna P, Joseph J, Clément J, Imai Y, Lareyre JJ, Laurent A, Galtier N, Baudat F, Duret L, Gagnaire PA, de Massy B. PRDM9 drives the location and rapid evolution of recombination hotspots in salmonid fish.. 2025. https://doi.org/10.1371/journal.pbio.3002950
PRDM9 targets recombination hotspots away from promoters and directs meiotic DNA double-strand breaks in vertebrates.
Aurore Sanchez, C. Adam, Felix Rauh, Yann Duroc, Lepakshi Ranjha, Bérangère Lombard, X. Mu, D. Loew, S. Keeney, Petr Cejka, R. Guérois, F. Klein, J. Charbonnier, V. Borde. Mechanism of in vivo activation of the MutLγ-Exo1 complex for meiotic crossover formation. 2019. https://doi.org/10.1101/2019.12.16.876623
Recombination machinery such as the MutLgamma complex associates directly with DNA double-strand break hotspots during meiotic crossover formation.
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