Multiple RNA-binding proteins can simultaneously bind to a single mRNA molecule

the verdict

SUPPORTED

the evidence backs this

Recorded sources

2 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Multiple RNA-binding proteins can and frequently do bind simultaneously to a single mRNA molecule, forming complex messenger ribonucleoprotein (mRNP) particles that cooperatively regulate gene expression.

The analysis

The claim asserts that multiple RNA-binding proteins can simultaneously bind to a single mRNA molecule. Papers [5] and [11] directly support this by demonstrating both natural multi-RBP co-occupancy on individual mRNPs and the cooperative functional effects of multiple RNA-binding proteins targeting the same mRNA transcript. The other papers discuss general RNA-protein interactions or multiprotein complexes without contradicting the statement. Thus, the evidence strongly supports the claim.

Evidence for · 2

Single-molecule quantitation of RNA-binding protein occupancy and stoichiometry defines a role for Yra1 (Aly/REF) in nuclear mRNP organization

Recorded source metadata

R. Asada, Andrew N M Dominguez, Ben Montpetit. Single-molecule quantitation of RNA-binding protein occupancy and stoichiometry defines a role for Yra1 (Aly/REF) in nuclear mRNP organization. 2023. https://doi.org/10.1016/j.celrep.2023.113415

This study uses single-molecule imaging to demonstrate that multiple copies of various RNA-binding proteins (such as Yra1, Nab2, and Npl3) simultaneously co-occupy individual nuclear mRNA molecules.

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More for · 1

Effective RNA Regulation by Combination of Multiple Programmable RNA-Binding Proteins

Recorded source metadata

Misaki Sugimoto, Akiyo Suda, S. Futaki, M. Imanishi. Effective RNA Regulation by Combination of Multiple Programmable RNA-Binding Proteins. 2020. https://doi.org/10.3390/APP10196803

This research shows that combining multiple programmable RNA-binding proteins targeting independent sequences on a single mRNA molecule effectively and cooperatively regulates transcript function.

Source citation format

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first checked01 Aug 2026

judged → SUPPORTED · 8301 Aug 2026

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