COVID-19 vaccines lower fertility rates and cause infertility.
Extensive clinical research, large-scale cohort studies, and systematic reviews consistently demonstrate that COVID-19 vaccines do not lower fertility rates or cause infertility in either men or women.
The claim that COVID-19 vaccines cause infertility is a specific and falsifiable assertion that has been thoroughly investigated by the scientific community. Numerous large cohort studies, systematic reviews, animal models, and assisted reproductive technology (ART) outcome analyses have directly tested this hypothesis and found no evidence of reproductive harm or diminished ovarian/sperm reserve. Consequently, the overwhelming weight of high-quality scientific evidence refutes the claim.
B. Ata, N. Vermeulen, E. Mocanu, L. Gianaroli, K. Lundin, S. Rautakallio-Hokkanen, J. Tapanainen, A. Veiga. SARS-CoV-2, fertility and assisted reproduction. 2022. https://doi.org/10.1093/humupd/dmac037
A comprehensive literature review of 148 papers found no evidence of a negative effect of SARS-CoV-2 vaccination on semen parameters, spermatogenesis, ovarian function, or pregnancy rates.
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Aharon Dick, Joshua I Rosenbloom, Einat Gutman-Ido, Naama Lessans, Adva Cahen-Peretz, Henry H Chill. Safety of SARS-CoV-2 vaccination during pregnancy- obstetric outcomes from a large cohort study. 2022. https://doi.org/10.1186/s12884-022-04505-5
A large cohort study on pregnancy outcomes found that SARS-CoV-2 vaccination is safe and does not negatively impact key reproductive and obstetric measures.
A. Braun, K. Feil, Elisabeth Reiser, Guenter Weiss, T. von Steuben, G. Pinggera, F. Köhn, B. Toth. Corona and Reproduction, or Why the Corona Vaccination Does Not Result in Infertility. 2022. https://doi.org/10.1055/a-1750-9284
A review of human and animal data concluded that corona vaccines have no negative impact on fertility, miscarriage rates, or live-birth rates.
Chao Wang, Min Wang, Guanjian Li, Bing Song, Q. Xing, Yunxia Cao. Effects of COVID-19 vaccination on human fertility: a post-pandemic literature review. 2023. https://doi.org/10.1080/07853890.2023.2261964
A post-pandemic review confirmed that while transient hormonal or seminal fluctuations can occur, vaccination does not reduce partner pregnancy probability or female fertility.
Jialyu Huang, Tianshu Guan, Lifeng Tian, Leizhen Xia, Dingfei Xu, Xingwu Wu, Lingling Huang, Mengyi Chen, Zheng Fang, Chaoyi Xiong, Liju Nie, Shuang Wang, Zengming Li, Yan Zhao, Qiongfang Wu. Impact of inactivated COVID-19 vaccination on female ovarian reserve: a propensity score-matched retrospective cohort study. 2023. https://doi.org/10.3389/fimmu.2023.1198051
A propensity score-matched cohort study demonstrated that inactivated COVID-19 vaccination has no measurable detrimental effect on female ovarian reserve as measured by AMH.
Meng Wang, Qiyu Yang, Lixia Zhu, Lei Jin. Investigating Impacts of CoronaVac Vaccination in Males on In Vitro Fertilization: A Propensity Score Matched Cohort Study. 2022. https://doi.org/10.5534/wjmh.220017
A prospective cohort study on male ART participants found that SARS-CoV-2 vaccination did not adversely affect gamete or embryonic development potential.
Wasan Nori, Dina Akeel Salman. Seminal fluid changes in the COVID-19 era: During infection and Post-vaccination. 2023. https://doi.org/10.1016/j.gocm.2023.04.001
An analysis of seminal fluid parameters reaffirmed vaccine safety, noting that any minor post-vaccination changes are transient and fully recover without causing infertility.
Yehao Dong, Zaihua Ba, Yining Qin, Jiao Ma, Yuqi Li, Yingze Zhang, Aijun Yang, Fei Chen. Comprehensive evaluation of inactivated SARS-CoV-2 vaccination on sperm parameters and sex hormones. 2024. https://doi.org/10.3389/fimmu.2024.1321406
A retrospective cohort study showed that various doses of inactivated COVID-19 vaccines do not negatively impact sperm parameters or key sex hormone levels.
Erol Karakaş, Orhan Yıldız, Büşra Karaca, A. Yay, Enes Karaman, M. Ermiş, E. Köseoğlu, Cem Artan. Effects on Ovarian Reserve of mRNA and Inactivated SARS-CoV-2 Vaccines Administered to Rats. 2025. https://doi.org/10.1007/s44411-025-00279-2
An animal model study using rats found normal ovarian morphology and unaffected ovarian reserve following mRNA and inactivated vaccine administration.
K. Palmerola, M. Bustillo, Marta Montenegro, Yaima Valdes, I. Collazo, J. Eisermann, Himanshu Arora. IMPACT OF COVID-19 VACCINATION ON ART OUTCOME. 2022. https://doi.org/10.1016/j.fertnstert.2022.08.566
A multicenter clinical analysis of IVF cycles demonstrated no significant differences in egg retrieval, maturation, or fertilization rates between vaccinated and unvaccinated patients.
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