Having cold hands causes physical pain due to vasoconstriction and ischemia
Evidence from physiological and epidemiological studies indicates that cold exposure causes peripheral vasoconstriction and ischemia, which leads to increased pain and discomfort in the extremities.
The claim is specific and testable regarding the physiological mechanisms of cold-induced pain. Multiple retrieved papers directly support the relationship between cold exposure, vasoconstriction/ischemia (or related vascular stasis), and the resulting increase in pain or musculoskeletal complaints in humans and animal models.
S. Cheung. Responses of the hands and feet to cold exposure. 2015. https://doi.org/10.1080/23328940.2015.1008890
Demonstrates that cold exposure causes strong vasoconstriction in extremities that increases physical pain.
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Zalaya K Ivy, J. Belcher, I. Khasabova, Chunsheng Chen, Joseph P Juliette, Fuad Abdulla, Conglin Ruan, Kaje Allen, J. Nguyen, Victoria M. Rogness, Joan D. Beckman, S. Khasabov, Kalpna Gupta, Ronald P Taylor, Donald A Simone, G. Vercellotti. Cold exposure induces vaso-occlusion and pain in sickle mice that depend on complement activation.. 2023. https://doi.org/10.1182/blood.2022019282
Shows that cold-induced vasoconstriction leads to ischemia and subsequent vaso-occlusive pain episodes in models of vascular stress.
A. Stjernbrandt, H. Pettersson, V. Wahlström, J. Wahlström, C. Lewis. Occupational cold exposure is associated with upper extremity pain. 2023. https://doi.org/10.3389/fpain.2023.1063599
Finds that occupational ambient cold exposure and cooling are significantly associated with musculoskeletal pain in the upper extremities.
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