Specific physiological mechanisms regulate the strength of motor signals
Specific physiological mechanisms, ranging from central neurotransmitter modulation to interoceptive visceral rhythms and neural strategies of motor unit control, directly regulate the strength of motor signals and corticospinal excitability.
The claim is specific and empirical, dealing with the regulation of motor signal strength via physiological mechanisms. Retrieved papers consistently demonstrate that mechanisms such as visceral rhythms, broad brain state features, and central neurotransmitter actions modulate corticospinal excitability and motor unit control. Therefore, the evidence overwhelmingly supports the claim.
Tahnée Engelen, T. Schuhmann, Alexander T Sack, Catherine Tallon-Baudry. Cardiac, respiratory, and gastric rhythms independently modulate motor corticospinal excitability in humans. 2025. https://doi.org/10.1371/journal.pbio.3003478
Paper [0] demonstrates that internal visceral rhythms independently modulate motor corticospinal excitability.
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Tahnée Engelen, T. Schuhmann, Alexander T. Sack, C. Tallon-Baudry. The cardiac, respiratory, and gastric rhythms independently modulate motor corticospinal excitability in humans. 2025. https://doi.org/10.1101/2024.09.10.612221
Paper [1] provides identical confirming evidence on how visceral bodily systems modulate motor corticospinal excitability.
Joel Frohlich, S. Ruch, B. Trunk, Marius Keute, P. Mediano, Alireza Gharabaghi. Brain signal complexity and aperiodicity predict human corticospinal excitability. 2025. https://doi.org/10.1101/2024.02.09.579457
Paper [2] shows that broad brain signal complexity features predict human corticospinal excitability.
Amoruso P, Lecce E, Scotto di Palumbo A, Sacchetti M, Bazzucchi I. Caffeine as an Ergogenic Aid for Neuromuscular Performance: Mechanisms of Action from Brain to Motor Units.. 2026. https://doi.org/10.3390/nu18020252
Paper [5] details how central neurotransmitter modulation and physiological agents tune motor system gain and alter corticospinal excitability.
Borzelli D, Pstrag K, Carollo G, Mena BB, Vieira TM. Sex differences in climbing endurance emerge from combined physiological adaptation and neural strategies.. 2026. https://doi.org/10.1007/s00421-026-06284-9
Paper [7] shows that distinct physiological muscle adaptations and neural strategies dictate motor unit control and performance.
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