There is a quantitative expression for steric hindrance
Quantitative expressions and descriptors for steric hindrance, such as Tolman's cone angle and computational estimation tools, are well established in chemistry to model molecular interactions.
The claim is specific, empirical, and directly supported by multiple retrieved studies that use quantitative metrics, descriptors, and computational estimators (such as Tolman's cone angle and STRIDER) to measure steric hindrance.
Gao X, Xu B, Tang X, Li M, Luo C, Wu F, Li X, Zhang L, Chen W. Dual Effect of Steric Hindrance in Non-Aqueous Amine Absorbents: Navigating the Trade-Off Between Kinetics and Thermodynamics for Efficient CO<sub>2</sub> Capture.. 2026. https://doi.org/10.1002/advs.74242
Introduces molecular descriptors to quantify steric hindrance and links them to performance via QSAR analyses.
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Radzilani F, Zinyemba O, Meijboom R. Application of statistical design of experiment to identify key factors in cross coupling reactions.. 2025. https://doi.org/10.1038/s41598-025-27005-w
Utilizes quantitative metrics like Tolman's cone angle to evaluate steric effects in ligands for cross-coupling reactions.
L Ponoop Prasad Patro, Thenmalarchelvi Rathinavelan. STRIDER: Steric hindrance estimator. 2020. https://doi.org/10.1101/2020.02.07.931550
Provides a computational web tool (STRIDER) to estimate and report pairwise steric hindrances using atomic radii.
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