Environmental and genetic factors are the primary causes of myopia
Extensive scientific literature confirms that the development of myopia is driven by a combination of genetic predispositions and environmental factors, such as educational pressure, near work, and lack of outdoor time.
Multiple comprehensive reviews, expert reports (such as from the International Myopia Institute), and genetic studies consistently demonstrate that myopia is a complex multifactorial condition caused by the interplay of genetic architecture and environmental exposures.
Ian G. Morgan, Pei‐Chang Wu, Lisa A. Ostrin, J. Willem L. Tideman, Jason C. Yam, Weizhong Lan, Rigmor C. Baraas, Xiangui He, Padmaja Sankaridurg, Seang‐Mei Saw, Amanda French, Kathryn Rose, Jeremy A. Guggenheim. IMI Risk Factors for Myopia. 2021. https://doi.org/10.1167/iovs.62.5.3
The review highlights confirmed causal links between environmental factors (education, outdoor time) and myopia development.
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Milly S. Tedja, Annechien E. G. Haarman, Magda A. Meester‐Smoor, Jaakko Kaprio, David A. Mackey, Jeremy A. Guggenheim, Christopher J. Hammond, Virginie J. M. Verhoeven, Caroline C. W. Klaver. IMI – Myopia Genetics Report. 2019. https://doi.org/10.1167/iovs.18-25965
The study outlines the significant genetic background of refractive error, identifying numerous genetic loci associated with myopia.
Loren Cordain, S. Boyd Eaton, Jennie Brand Miller, Staffan Lindeberg, Clark Jensen. An evolutionary analysis of the aetiology and pathogenesis of juvenile‐onset myopia. 2002. https://doi.org/10.1034/j.1600-0420.2002.800203.x
The evolutionary analysis concludes that both genes and environmental factors play a crucial role in juvenile-onset myopia.
Sayantan Biswas, Antonio El Kareh, Mariyem Qureshi, Deborah Mei Xuan Lee, Chen‐Hsin Sun, Janice Lam, Seang‐Mei Saw, Raymond P. Najjar. The influence of the environment and lifestyle on myopia. 2024. https://doi.org/10.1186/s40101-024-00354-7
The comprehensive review emphasizes the profound influence of environmental and lifestyle factors, such as outdoor time and near work, on myopia.
Noelia Martínez-Albert, Inmaculada Bueno-Gimeno, Andrés Gené‐Sampedro. Risk Factors for Myopia: A Review. 2023. https://doi.org/10.3390/jcm12186062
The review confirms that myopia etiology is associated with both genetic background and key environmental factors like education and outdoor activity.
Yumeng Wang, Shi Yao Lu, Xiu Juan Zhang, Li Jia Chen, Chi‐Pui Pang, Jason C. Yam. Myopia Genetics and Heredity. 2022. https://doi.org/10.3390/children9030382
The report notes that myopia is greatly influenced by genetics alongside primary external lifestyle factors like near work and outdoor time.
Alfred Pozarickij, Cathy Williams, Pirro G. Hysi, Jeremy A. Guggenheim, Tariq Aslam, Sarah Barman, Jenny H. Barrett, Paul Bishop, Peter Blows, Catey Bunce, Roxana O. Carare, Usha Chakravarthy, Michelle Chan, Sharon Chua, David P. Crabb, Philippa M. Cumberland, Alexander Day, Parul Desai, Bal Dhillon, Andrew D. Dick, Cathy Egan, Sarah Ennis, Paul J. Foster, Marcus Fruttiger, John Gallacher, David F. Garway‐Heath, Jane Whitney Gibson, Dan Gore, Christopher J. Hammond, Alison J. Hardcastle, Simon Harding, Ruth Hogg, Pearse A. Keane, Peng T. Khaw, Anthony P. Khawaja, Gerassimos Lascaratos, Andrew Lotery, Tom Mac Gillivray, Sarah Mackie, Keith R. Martin, Michelle McGaughey, Bernadette McGuinness, Gareth J. McKay, Martin McKibbin, Danny Mitry, Tony Moore, James E. Morgan, Zaynah Muthy, Eoin O’Sullivan, Christopher G. Owen, Praveen J. Patel, Euan Paterson, Tünde Pető, Axel Petzold, Jugnoo S. Rahi, Alicja R. Rudnikca, Jay Self, Sobha Sivaprasad, David Steel, Irene Stratton, Nicholas G. Strouthidis, Cathie Sudlow, Dhanes Thomas, Emanuele Trucco, Adnan Tufail, Véronique Vitart, S A Vernon, Ananth C. Viswanathan, Katie Williams, Jayne V. Woodside, Max Yates, Jennifer Yip, Yalin Zheng. Quantile regression analysis reveals widespread evidence for gene-environment or gene-gene interactions in myopia development. 2019. https://doi.org/10.1038/s42003-019-0387-5
The study confirms that genetic variants exhibit interactions with environmental factors in myopia development.
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