LSD induces functional connectivity between disparate sensory regions in the brain

the verdict

SUPPORTED

the evidence backs this

Recorded sources

2 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Neuroimaging studies demonstrate that LSD alters brain network organization by increasing functional coupling and crosstalk between disparate sensory and association regions.

The analysis

Papers [3] and [4] provide direct neuroimaging evidence that LSD increases functional connectivity and crosstalk between distinct sensory and cortical networks. The other papers are either reviews, focus on different drugs, or examine different structural/behavioral metrics. Thus, the claim is fully supported by the evidence.

Evidence for · 2

LSD-induced changes in the functional connectivity of distinct thalamic nuclei.

Recorded source metadata

Stefano Delli Pizzi, Piero Chiacchiaretta, Carlo Sestieri, Antonio Ferretti, Maria Giulia Tullo, Stefania Della Penna, Giovanni Martinotti, Marco Onofrj, Leor Roseman, Christopher Timmermann, David J Nutt, Robin L Carhart-Harris, Stefano L Sensi. LSD-induced changes in the functional connectivity of distinct thalamic nuclei.. 2023. https://doi.org/10.1016/j.neuroimage.2023.120414

LSD intake increased thalamocortical functional connectivity between subcortical nuclei and sensory cortices such as the somatosensory and auditory networks.

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More for · 1

Serotonergic psychedelic drugs LSD and psilocybin reduce the hierarchical differentiation of unimodal and transmodal cortex.

Recorded source metadata

Manesh Girn, Leor Roseman, Boris Bernhardt, Jonathan Smallwood, Robin Carhart-Harris, R Nathan Spreng. Serotonergic psychedelic drugs LSD and psilocybin reduce the hierarchical differentiation of unimodal and transmodal cortex.. 2022. https://doi.org/10.1016/j.neuroimage.2022.119220

LSD administration reduced the hierarchical differentiation of the brain, resulting in increased unimodal-transmodal crosstalk.

Source citation format

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first checked01 Aug 2026

judged → SUPPORTED · 7501 Aug 2026

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