Indoor mold growth causes Chronic Inflammatory Response Syndrome

Hyvönen S, Lohi J, Tuuminen T. Moist and Mold Exposure is Associated With High Prevalence of Neurological Symptoms and MCS in a Finnish Hospital Workers Cohort.. 2020. https://doi.org/10.1016/j.shaw.2020.01.003

Exposure to dampness and mold in a hospital cohort is associated with a high prevalence of central and peripheral nervous system symptoms and multi-system illness.

Gunn SR, Gunn GG, Mueller FW. Reversal of Refractory Ulcerative Colitis and Severe Chronic Fatigue Syndrome Symptoms Arising from Immune Disturbance in an HLA-DR/DQ Genetically Susceptible Individual with Multiple Biotoxin Exposures.. 2016. https://doi.org/10.12659/ajcr.896949

A case report demonstrates that mycotoxin and toxic mold exposure in a genetically susceptible individual leads to chronic inflammatory response syndrome (CIRS) symptoms.

Ryan Shoemaker, J Meinhardt, A Heyman, D Lark. Exposure to Actinobacteria resident in water-damaged buildings and resultant immune injury in Chronic Inflammatory Response Syndrome. 2021. https://doi.org/10.18103/mra.v9i10.2585

Research outlines how exposure to water-damaged building microbiota, such as Actinobacteria, triggers innate immune activation characteristic of CIRS.

Ming Dooley. Biomarkers Over Time: From Visual Contrast Sensitivity to Transcriptomics in Differentiating Chronic Inflammatory Response Syndrome and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. 2025. https://doi.org/10.20944/preprints202506.1142.v1

A review highlights the reproducibility of the CIRS framework, linking environmentally acquired illnesses and innate immune activation to indoor exposure biomarkers.