Axons use molecular recognition molecules to avoid self-synapsing with their own neuron
Axons and neurons utilize cell surface molecular recognition molecules, such as Dscam and protocadherins, to provide unique cellular identities and mediate self-avoidance or prevent self-synapsing.
The retrieved papers thoroughly establish that neural circuits rely on diverse cell adhesion and recognition molecules (such as Dscam and clustered protocadherins) to mediate self-avoidance, self/non-self discrimination, and proper axonal patterning.
Jin Y, Li H. Revisiting Dscam diversity: lessons from clustered protocadherins.. 2019. https://doi.org/10.1007/s00018-018-2951-4
Discusses how extraordinary recognition diversity of cell surface molecules like Dscam and clustered protocadherins prevents inappropriate interactions and wires neural circuits.
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Dong H, Yang X, Wu L, Zhang S, Zhang J, Guo P, Du Y, Pan C, Fu Y, Li L, Shi J, Zhu Y, Ma H, Bian L, Xu B, Li G, Shi F, Huang J, He H, Jin Y. A systematic CRISPR screen reveals redundant and specific roles for Dscam1 isoform diversity in neuronal wiring.. 2023. https://doi.org/10.1371/journal.pbio.3002197
Demonstrates that diverse isoforms of cell adhesion molecules such as Dscam1 are critical for self-discrimination and proper axonal patterning.
Xiong Y, Li L, Zhang X. Exploring perspectives of Dscam for cognitive deficits: a review of multifunction for regulating neural wiring in homeostasis.. 2025. https://doi.org/10.3389/fnmol.2025.1575348
Highlights how transmembrane receptors like Dscam use extensive isoform diversity and homophilic interactions to establish unique cellular identities and avoid incorrect connectivity.
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