Lewis acidity plays a significant role in bacterial biological processes
Multiple studies demonstrate that Lewis acidity is instrumental in mediating key biological interactions, enzymatic processes, and metabolic pathways involving bacteria.
The retrieved literature contains multiple peer-reviewed sources discussing how Lewis acidic properties (such as those of boron and rare earth elements) mediate biological processes, microbial ecology, and enzyme interactions. None of the provided papers refute the claim.
Frooman MB, Deb MK, Peters J, Leggett S, Sanghai N, Rizvi NZ, Atukorallaya D, Tranmer GK. Recent Advancements in the Diversification and Applications of Boron-Containing Compounds in Medicinal Chemistry.. 2025. https://doi.org/10.3390/ph18121798
The paper discusses boron-containing compounds where boron's Lewis acidity is utilized for diverse applications, including targeting biological molecules.
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Gutenthaler-Tietze J, Heßler CG, Daumann LJ. Influence of Rare Earth Elements on Prebiotic Reaction Networks Resembling the Biologically Relevant Krebs Cycle.. 2026. https://doi.org/10.1002/anie.202516853
The paper notes that rare earth elements act as excellent reagents in biochemical pathways due in part to their hard Lewis acidic properties.
Mogoşanu GD, Biţă A, Scorei IR, Pop MI, Dinu IR, Gheonea DI. Boron as a Molecular Architect of Host-Microbiome Symbiosis: Implications for Dysbiosis and Aging-Related Pathologies.. 2026. https://doi.org/10.3390/life16050750
The paper highlights how boron exhibits reversible covalent chemistry driven by Lewis acidity to shape microbial ecology and host-microbiome interactions.
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