The human body can switch to a metabolic starvation mode.
The human body exhibits metabolic flexibility, undergoing coordinated neuroendocrine and metabolic adaptations in response to fasting or starvation.
The retrieved papers document metabolic flexibility, neuroendocrine changes, and substrate utilization shifts during fasting and caloric restriction in humans, supporting the claim that the body adapts metabolically to starvation.
Reuben L. Smith, Maarten R. Soeters, Rob C. I. Wüst, Riekelt H. Houtkooper. Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease. 2018. https://doi.org/10.1210/er.2017-00211
Paper 2 discusses metabolic flexibility as an essential adaptation mechanism during caloric restriction and starvation.
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Jean L. Chan, Kathleen Heist, Alex M. DePaoli, Johannes D. Veldhuis, Christos S. Mantzoros. The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. 2003. https://doi.org/10.1172/jci17490
Paper 3 demonstrates the neuroendocrine and metabolic adaptations that occur in healthy men during short-term starvation.
Jean L. Chan, Kathleen Heist, Alex M. DePaoli, Johannes D. Veldhuis, Christos S. Mantzoros. The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. 2003. https://doi.org/10.1172/jci200317490
Paper 4 confirms the physiological and metabolic adaptations observed during human fasting.
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