Spike-timing-dependent plasticity and homeostatic plasticity operate through different biological mechanisms

The retrieved literature examines the molecular and cellular mechanisms of both spike-timing-dependent plasticity (STDP) and homeostatic plasticity (such as presynaptic homeostatic plasticity). Studies like Paper 1 highlight mechanisms involving endocannabinoids and astrocytic calcium signaling for STDP, while Paper 7 demonstrates distinct pathways like Protein Kinase D for homeostatic plasticity. Although both are forms of synaptic plasticity, the underlying biological mechanisms are fundamentally distinct, supporting the claim.