Individuals with autism have a greater genetic predisposition to psychosis and schizophrenia
Multiple large-scale genetic and transcriptomic studies demonstrate a significant genetic overlap and positive genetic correlation between autism spectrum disorder and schizophrenia, supporting the claim that individuals with autism carry a greater genetic predisposition to psychosis.
The retrieved papers provide robust genomic, transcriptomic, and pathway-level evidence demonstrating a clear genetic overlap and positive genetic correlation between autism spectrum disorder (ASD) and schizophrenia (SCZ). Studies like those by the cross-disorder genomics groups and transcriptomic profiling explicitly confirm shared genetic architecture, common loci, and similar molecular pathways, supporting the claim without contradictory evidence among the provided sources.
N. Khanzada, M. Butler, A. Manzardo. GeneAnalytics Pathway Analysis and Genetic Overlap among Autism Spectrum Disorder, Bipolar Disorder and Schizophrenia. 2017. https://doi.org/10.3390/ijms18030527
Identifies overlapping genes and pathways among autism spectrum disorder, bipolar disorder, and schizophrenia, pointing to shared genetic and neurobiological underpinnings.
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Iman Sadeghi, J. Gispert, Emilio Palumbo, Manuel Muñoz-Aguirre, Valentin Wucher, V. D’Argenio, G. Santpere, A. Navarro, R. Guigó, N. Vilor-Tejedor. Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders. 2021. https://doi.org/10.1016/j.csbj.2022.08.037
Reveals similar transcriptome-wide alterations between autism spectrum disorder and schizophrenia, indicating shared molecular pathobiology.
Yu Chen, Wenqiang Li, L. Lv, Weihua Yue. Shared Genetic Determinants of Schizophrenia and Autism Spectrum Disorder Implicate Opposite Risk Patterns: A Genome-Wide Analysis of Common Variants.. 2024. https://doi.org/10.1093/schbul/sbae044
Reports a significant positive genetic correlation between schizophrenia and autism spectrum disorder, identifying jointly influencing genomic loci and shared developmental gene enrichment.
Joana Vilela, H. Martiniano, A. Marques, João Xavier Santos, C. Rasga, G. Oliveira, A. Vicente. Disease similarity network analysis of Autism Spectrum Disorder and comorbid brain disorders. 2022. https://doi.org/10.3389/fnmol.2022.932305
Demonstrates that autism spectrum disorder shares a genetic component and network community with conditions in the schizophrenia spectrum.
Felicity V. Larson, J. Arrand, D. Tantam, Peter B. Jones, A. Holland. Copy number variants in people with autism spectrum disorders and co-morbid psychosis.. 2017. https://doi.org/10.1016/j.ejmg.2017.12.005
Identifies rare copy number variants and affected genetic regions in individuals dually diagnosed with autism spectrum disorder and psychosis.
Baiqiang Xue, Mingming Niu, Yuanchao Sun, Lin Wang, Chuanhong Wu, Yonghe Ding, Baokun Wang, Lixia Peng, Xiangyu Li, Haiyan Song, Wenli Yuan, Weiye Shi, Junting Liu, Chengwen Gao, Xiangzhong Zhao, Qian Zhang, Zhiqiang Li. Detection of Pleiotropic Genetic Factors and Critical Brain Cell Types Linking Insomnia with Psychiatric Disorders.. 2025. https://doi.org/10.1093/sleep/zsaf317
Finds significant genetic correlations and shared loci between autism spectrum disorder, schizophrenia, and other psychiatric conditions.
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