Eukaryotic organisms have introns to enable alternative splicing and regulation

the verdict

SUPPORTED

the evidence backs this

Recorded sources

4 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Eukaryotic organisms possess introns that are removed via pre-mRNA splicing, which is widely documented to enable alternative splicing, expand proteome diversity, and regulate gene expression.

The analysis

The retrieved papers consistently support the well-established biological function of introns in eukaryotes, highlighting their role in pre-mRNA processing, alternative splicing expansion of the proteome, and gene expression regulation. No papers contradict this premise.

Evidence for · 4

Mechanisms and Regulation of Alternative Pre-mRNA Splicing

Recorded source metadata

Yeon J. Lee, D. Rio. Mechanisms and Regulation of Alternative Pre-mRNA Splicing. 2015. https://doi.org/10.1146/annurev-biochem-060614-034316

States that precursor mRNA splicing provides significant expansion of the functional proteome in eukaryotic organisms via alternative splicing and gene regulation.

Source citation format

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More for · 3

A broad analysis of splicing regulation in yeast using a large library of synthetic introns

Recorded source metadata

Dvir Schirman, Z. Yakhini, Yitzhak Pilpel, Orna Dahan. A broad analysis of splicing regulation in yeast using a large library of synthetic introns. 2021. https://doi.org/10.1371/journal.pgen.1009805

Discusses how introns are shaped in evolution to allow cells to regulate their transcriptome and facilitate alternative splicing.

Source citation format

Alternative RNA splicing in cancer: what about adult T-cell leukemia?

Recorded source metadata

Julie Tram, J. Mesnard, J. Péloponèse. Alternative RNA splicing in cancer: what about adult T-cell leukemia?. 2022. https://doi.org/10.3389/fimmu.2022.959382

Explains that alternative splicing allows almost 95% of human protein-encoding genes to produce transcripts with different exon combinations, increasing proteome diversity.

Source citation format

Structural-Functional Dynamics of Group II Introns in Plant Mitochondria: Splicing Diversity-Driven Genome Plasticity and Regulatory Adaptation

Recorded source metadata

Kai Chen, Ting Wang, Yingjuan Su. Structural-Functional Dynamics of Group II Introns in Plant Mitochondria: Splicing Diversity-Driven Genome Plasticity and Regulatory Adaptation. 2025. https://doi.org/10.1360/csb-2025-0378

Notes that introns perform critical functions in regulating gene expression through splicing mechanisms, including the regulation of alternative splicing by cis-acting elements.

Source citation format

The paper trail · every fact has a biography

first checked01 Aug 2026

judged → SUPPORTED · 9401 Aug 2026

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