Side effects compromise the blinding in clinical studies

the verdict

SUPPORTED

the evidence backs this

Recorded sources

3 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Clinical trial evidence confirms that noticeable side effects can compromise study blinding by revealing treatment allocations to participants and personnel.

The analysis

The retrieved literature contains multiple specific examples demonstrating that adverse events and side effects (such as skin reactions, distinctive psychoactive effects, or lisinopril-induced cough and angioedema) can cause unblinding in clinical studies. No papers contradict this premise.

Evidence for · 3

Specific-class Skin Side-effects of Drugs Might Compromise Blinding in Randomized Controlled Trials

Recorded source metadata

Giao Do-Pham, Annabel Maruani, Sophie Leducq, Bruno Giraudeau, Olivier Chosidow. Specific-class Skin Side-effects of Drugs Might Compromise Blinding in Randomized Controlled Trials. 2023. https://doi.org/10.2340/actadv.v103.3364

Demonstrates that specific class skin side-effects of drugs can compromise blinding in randomized controlled trials.

Source citation format

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More for · 2

Safety and tolerability of the ACE-inhibitor lisinopril among Nigerian adults with HIV: preliminary pilot data from a randomized clinical trial.

Recorded source metadata

Dankishiya FS, Muhammad H, Wudil UJ, Musa BM, Du L, Adam IA, Ahonkhai AA, Burgner AM, Nalado AM, Sani MU, Abdu A, Shepherd BE, Aliyu MH, Wester CW. Safety and tolerability of the ACE-inhibitor lisinopril among Nigerian adults with HIV: preliminary pilot data from a randomized clinical trial.. 2026. https://doi.org/10.1007/s00210-026-05280-2

Notes that adverse events like persistent cough and angioedema led to unblinding in participants taking lisinopril.

Source citation format

Overcoming blinding confounds in psychedelic randomized controlled trials using biomarker driven causal mediation analysis

Recorded source metadata

Suresh Muthukumaraswamy. Overcoming blinding confounds in psychedelic randomized controlled trials using biomarker driven causal mediation analysis. 2023. https://doi.org/10.31234/osf.io/d52ay

Highlights how distinctive psychoactive side effects cause unblinding and expectancy effects in psychedelic randomized controlled trials.

Source citation format

The paper trail · every fact has a biography

first checked02 Aug 2026

judged → SUPPORTED · 7802 Aug 2026

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