Reaction reversibility is determined by thermodynamic and kinetic factors of the specific step
Chemical reaction reversibility and selectivity are fundamentally governed by both thermodynamic properties and kinetic factors.
The retrieved literature consistently confirms that chemical and biochemical reaction reversibility is dependent on both thermodynamic factors (such as free energy changes, entropy, and equilibrium states) and kinetic factors (such as activation barriers, reaction pathways, and rate control).
Hatano H, Fernandes VA, Mukherjee S, Zhu C, Takahira A, Jiang P, Jin M, Harabuchi Y, Staub R, Gao M, Varnek A, Maeda S, Tsuji N, List B. Catalytic Asymmetric Hydration of Alkenes.. 2026. https://doi.org/10.1021/jacs.6c06916
Paper [0] demonstrates that alkene hydration reversibility is governed by unfavorable thermodynamic entropy and reaction temperatures.
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Gao D, Wu X, Huang Y, Li B. Quantum chemistry unifies phosphorus removal and recovery through environmental affinity.. 2026. https://doi.org/10.1016/j.watres.2026.126256
Paper [1] notes that environmental affinity and reversibility are jointly regulated by thermodynamic retention, activation barriers, and kinetic accessibility.
Tu JL, Guo L, Huang B, Xia W. Interpreting terminal selectivity in undirected C(sp<sup>3</sup>)-H functionalization: kinetic insights and mechanistic implications.. 2026. https://doi.org/10.1039/d6sc02478e
Paper [2] shows how site selectivity and reversibility emerge from the interplay of kinetic regimes and thermodynamic effects.
Zheng W, Fang S, Zhu C, Yang L, Meng Y, Yang L, Wu J. Enhancing Diastereoselectivity of l‑Threonine Aldolase by Strengthening Kinetic Control To Mitigate Thermodynamic Equilibrium.. 2026. https://doi.org/10.1021/cbe.6c00020
Paper [3] highlights that enzymatic aldol reactions are governed by the balance between kinetic control and thermodynamic equilibrium.
Nuñez-Vargas D, Barraza-Burgos J, Guerrero-Perez J, Diaz L, Dalai AK, Borugadda VB. Oil Palm Shell-Derived Activated Carbon: Adsorption Kinetics, Thermodynamics, and Interaction Mechanism for Lufenuron 50-EC Pesticide.. 2026. https://doi.org/10.1021/acsomega.4c10096
Paper [5] indicates that adsorption reversibility is dictated by thermodynamic spontaneity and kinetic models.
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