COVID-19 causes myocardial infarctions
Multiple clinical studies and population-based cohorts demonstrate that COVID-19 infection triggers systemic inflammation and a hypercoagulable state that significantly increases the risk of acute myocardial infarction and other major cardiovascular events, particularly in the weeks following infection.
The retrieved literature consistently supports the association between COVID-19 and acute myocardial infarctions or major adverse cardiovascular events, noting a well-defined hazard window immediately following infection. Papers [1], [2], and [3] provide direct clinical and epidemiological evidence linking COVID-19 to subsequent cardiovascular events and ASCVD, while papers [0], [4], and [5] provide contextual and supportive evidence regarding viral-induced cardiac strain and risk mitigation.
Howick V JF, Gersh BJ, Scott CG, Chamberlain A, Shapiro B, McLeod CJ, van Niekerk CJ, Taylor B, Fairweather D, Sanchez CV, Utset M, Vardar U, McBane RD 2nd, Raphael C, Kiernan J, Kafil T, Cooper LT Jr, Bois JP. Time-Critical Cardiovascular Risk After COVID-19: A Population-Based Analysis Across Variant Eras.. 2026. https://doi.org/10.1016/j.mayocpiqo.2026.100721
This population-based study demonstrates an elevated risk of major adverse cardiovascular events clustered within the first 30 days following SARS-CoV-2 infection.
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Filev R, Bogov B, Hadjieva R, Kalinov K, Hristova J, Svinarov D, Rostaing L. Association of Acute-Phase IL-6 and SAA with Cardiovascular Events and Mortality Six Years After COVID-19 Infection: An Observational Cohort Study.. 2026. https://doi.org/10.3390/ijms27114721
This observational study finds that acute inflammatory markers during COVID-19 infection are associated with long-term cardiovascular outcomes, including myocardial infarction.
Kämpe J, Jonson M, Rubenson Wahlin R, Hollenberg J, Svensson P, Nordberg P. Beyond recovery: long-term cardiovascular risks after severe COVID-19 requiring intensive care.. 2026. https://doi.org/10.1186/s13054-026-06088-5
This matched cohort study shows that survivors of severe COVID-19 experience an increased risk of atherosclerotic cardiovascular disease (ASCVD) during follow-up.
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