Unexplained sadness can arise from subconscious physiological and psychological triggers.
Unexplained sadness and mood shifts are often driven by underlying neurobiological and psychological processes, such as baseline neural activity fluctuations and stress responses.
The claim is specific, empirical, and contestable, passing Step 0. The retrieved literature includes neuro-computational and psychophysiological studies demonstrating that mood fluctuations and emotional distress are underpinned by physiological mechanisms, brain valuation region activities, and stress-related psychological triggers.
Fabien Vinckier, Lionel Rigoux, Delphine Oudiette, Mathias Pessiglione. Neuro-computational account of how mood fluctuations arise and affect decision making. 2018. https://doi.org/10.1038/s41467-018-03774-z
Paper 2 demonstrates how baseline neural fluctuations integrate emotional experiences to produce mood changes.
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Maroti D, Frisch S, Lumley MA. To feel is to heal-introduction to Emotional Awareness and Expression Therapy.. 2025. https://doi.org/10.1007/s00482-025-00878-6
Paper 7 discusses how somatic and emotional symptoms can be precipitated and prolonged by psychological processes and unresolved conflicts.
Eroume A Egom E, Lema BS. Integrating Emotional Stress and Lipid Lowering in Cardiovascular Disease Management: The Future of Precision Cardiovascular Prevention.. 2025. https://doi.org/10.3390/jcm14207208
Paper 10 highlights emotional and psychosocial stress as biologically active determinants that trigger physical and psychological stress responses.
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