Caffeine has significant effects on the mammalian circulatory system
Multiple studies demonstrate that caffeine exerts measurable physiological effects on the mammalian circulatory system, including influences on blood pressure, heart rate, vascular resistance, and autonomic nervous system activity.
The retrieved papers consistently document caffeine's pharmacological mechanisms and physiological impacts on the cardiovascular and circulatory systems, including changes in blood pressure, heart rate variability, and receptor antagonism. There is no evidence refuting that caffeine affects the circulatory system, making the claim well-supported.
Kinga Marcinek, B. Luzak, M. Rozalski. The Effects of Caffeine on Blood Platelets and the Cardiovascular System through Adenosine Receptors. 2024. https://doi.org/10.3390/ijms25168905
Reviews how caffeine interacts with adenosine receptors to modulate coronary blood flow, peripheral resistance, and heart rate.
See more details
Joseph Mandato, Rei Kola, T. Tyson, Luke J. Laffin, Robert W. Bales. The Effects of Energy Drinks on the Cardiovascular System: A Systematic Review. 2025. https://doi.org/10.1007/s11886-025-02293-w
Finds that caffeinated energy drinks cause significant cardiovascular effects like increased heart rate, blood pressure, and QTc interval prolongation.
A. K. Hamad. Caffeine and Arrhythmias: A Critical Analysis of Cardiovascular Responses and Arrhythmia Susceptibility. 2024. https://doi.org/10.37616/2212-5043.1402
Examines caffeine's pharmacological properties and its arrhythmogenic potential on the cardiovascular system.
Ş. Çalışkan. Acute Effects of Caffeine and Taurine on Linear and Nonlinear Measures of the Cardiovascular System in Young Adults. 2024. https://doi.org/10.3390/app14114912
Demonstrates that acute caffeine consumption significantly affects hemodynamic parameters and heart rate variability.
Lucas Braga Albino, R. Sordi, J. G. Oliveira, Daniel Fernandes. Dose and Time-Dependent Effects of Caffeine on Cardiovascular Changes Induced by Adenosine. 2023. https://doi.org/10.1590/1678-4324-2023220644
Shows that caffeine successfully blocks adenosine-induced changes in blood pressure, renal blood flow, and heart rate.
Sascha Ketelhut, Carole Gassner, Claudio Nigg. EFFECTS OF CAFFEINE ON BLOOD PRESSURE AND HEART RATE VARIABILITY AT REST AND DURING COLD PRESSOR TEST. 2022. https://doi.org/10.1097/01.hjh.0000837876.08919.cf
Observes that caffeine alters autonomic nervous system control of heart rate and HRV indices during physical stress.
Nupur Srivastava, D Sarkar. EFFECT OF CAFFEINE ON SYSTOLIC BLOOD PRESSURE AND HEART RATE IN HEALTHY YOUNG ADULTS. 2023. https://doi.org/10.36106/ijar/8601362
Notes that caffeine increases systolic blood pressure, mean arterial pressure, and heart rate by acting on vascular receptors and hormones.
The paper trail · every fact has a biography
Challenge the receipt
Citation formatting by citeproc-js (Frank Bennett) and the Citation Style Language project. Source and licenses.
Terms · Privacy · How verdicts work · Dispute this receipt