Depolymerisation takes place at the minus end of microtubules

the verdict

SUPPORTED

the evidence backs this

Recorded sources

3 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Microtubules undergo depolymerization and dynamic transitions at their minus ends, though these ends are typically more stable than the plus ends.

The analysis

The retrieved papers all discuss microtubule minus ends undergoing dynamics, disassembly, and depolymerization, directly supporting the claim. No papers refute the statement.

Evidence for · 3

Non-centrosomal microtubule formation and measurement of minus end microtubule dynamics in A498 cells

Recorded source metadata

Anne-Marie C. Yvon, Patricia Wadsworth. Non-centrosomal microtubule formation and measurement of minus end microtubule dynamics in A498 cells. 1997. https://doi.org/10.1242/jcs.110.19.2391

Paper [0] measures the dynamic behavior of both ends of microtubules, confirming that minus ends undergo complete disassembly and transitions.

Source citation format

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More for · 2

GTP-tubulin loves microtubule plus ends but marries the minus ends

Recorded source metadata

Linda Wordeman. GTP-tubulin loves microtubule plus ends but marries the minus ends. 2019. https://doi.org/10.1083/jcb.201908039

Paper [1] discusses the off-rate for tubulin and the transition to disassembly at microtubule minus ends.

Source citation format

Multimerization and tubulin binding are required for the SPIRAL2 protein to localize to and stabilize microtubule minus ends

Recorded source metadata

Yuanwei Fan, Natasha Bilkey, Ram Dixit. Multimerization and tubulin binding are required for the SPIRAL2 protein to localize to and stabilize microtubule minus ends. 2021. https://doi.org/10.1101/2021.10.05.463238

Paper [2] investigates proteins that regulate and decrease the depolymerization rate specifically at microtubule minus ends, confirming that depolymerization occurs there.

Source citation format

The paper trail · every fact has a biography

first checked01 Aug 2026

judged → SUPPORTED · 8601 Aug 2026

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