Long-term potentiation is definitively linked with brain plasticity
Long-term potentiation (LTP) is widely recognized and extensively evidenced as a foundational mechanism of brain plasticity, supporting learning, memory, and structural remodeling across neural circuits.
The retrieved literature universally supports the foundational neuroscience consensus that long-term potentiation (LTP) is a core mechanism of synaptic and brain plasticity. Multiple studies across various brain regions, receptor systems, and methodological approaches confirm this link.
Yire Jeong, Hye-Yeon Cho, Mujun Kim, Jung-Pyo Oh, Min Soo Kang, Miran Yoo, Han-Sol Lee, Jin-Hee Han. Synaptic plasticity-dependent competition rule influences memory formation. 2021. https://doi.org/10.1038/s41467-021-24269-4
Paper [0] demonstrates how manipulating long-term potentiation and depression directly governs neural competition and memory encoding.
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C. A. M. de León-López, Marta Carretero‐Rey, Zafar U. Khan. AMPA Receptors in Synaptic Plasticity, Memory Function, and Brain Diseases. 2025. https://doi.org/10.1007/s10571-024-01529-7
Paper [1] reviews how AMPA receptor trafficking mediates both forms of synaptic plasticity and memory function.
Alessandro Tozzi, Laura Bellingacci, V. Pettorossi. Rapid Estrogenic and Androgenic Neurosteroids Effects in the Induction of Long-Term Synaptic Changes: Implication for Early Memory Formation. 2020. https://doi.org/10.3389/fnins.2020.572511
Paper [2] shows that neurosteroids regulate long-term potentiation and depression, which are crucial for neural circuit plasticity.
M. Ferrer-Ferrer, Shaobo Jia, R. Kaushik, J. Schneeberg, I. Figiel, S. Aleshin, A. Mironov, M. Safari, R. Frischknecht, J. Włodarczyk, O. Senkov, A. Dityatev. Mice deficient in synaptic protease neurotrypsin show impaired spaced long-term potentiation and blunted learning-induced modulation of dendritic spines. 2023. https://doi.org/10.1007/s00018-023-04720-z
Paper [3] links neurotrypsin deficiency to impaired long-term potentiation and disrupted dendritic spine modulation.
M. Azarfarin, Tahereh Ghadiri, Masoomeh Dadkhah, Sajad Sahab-Negah. The interaction between cannabinoids and long‐term synaptic plasticity: A survey on memory formation and underlying mechanisms. 2024. https://doi.org/10.1002/cbf.4100
Paper [4] outlines synaptic plasticity, including long-term potentiation, as foundational for memory and cognitive maintenance.
Rahul Gupta, Cian O’Donnell. Dendritic spine neck plasticity controls synaptic expression of long-term potentiation. 2023. https://doi.org/10.1101/2023.01.27.525952
Paper [5] uses computational modeling to show how spine neck properties mechanistically regulate long-term potentiation.
Kevin Chua, Y. Chong, Sreedharan Sajikumar. D1/D5 receptor activation promotes long‐term potentiation and synaptic tagging/capture in hippocampal area CA2. 2025. https://doi.org/10.1111/febs.70266
Paper [6] establishes that dopamine D1 receptor activation primes area CA2 for long-term potentiation and synaptic plasticity.
Drew VJ, Woo J, Lee JM, Koh W, Won J, Lee JH, Lee CJ. A TREK-1/AQP4/TRPA1/BDNF Signaling Axis Is Associated With Astrocytic Volume Transients, Synaptic Plasticity, and Spatial Memory.. 2026. https://doi.org/10.1002/glia.70195
Paper [7] links astrocytic volume transients and BDNF signaling to the modulation of long-term potentiation and synaptic plasticity.
Rodríguez-Moreno A, Paulsen O. Long-term potentiation in the brain: a synaptic memory mechanism.. 2026. https://doi.org/10.1152/physrev.00028.2025
Paper [8] comprehensively reviews long-term potentiation as a core mechanism of neuroplasticity and memory.
Lin S, Hao S, Wu Y, Liu W, Wang J, Li L, Liu W, Tao W, Zhuo M. Biphasic synaptic plasticity of the medial thalamic-cingulate pathway contributes to pain hypersensitivity in vivo.. 2026. https://doi.org/10.1177/17448069261466896
Paper [9] identifies long-term potentiation and depression in the thalamus-ACC pathway as key mechanisms of central synaptic plasticity.
Ojea Ramos S, Medina C, Krawczyk MDC, Millan J, Acutain MF, Romano AG, Baez MV, Urbano FJ, Boccia MM, Feld M. Hippocampal ERK2 dimerization regulates inhibitory avoidance memory reconsolidation and synaptic plasticity.. 2026. https://doi.org/10.1016/j.isci.2026.116649
Paper [10] shows that blocking ERK2 dimerization impairs both memory reconsolidation and long-term potentiation.
Kansala C, St. Jean J, Nkansah-Okoree V, Rouleau N, Murugan NJ. LTP-patterned electromagnetic stimulation induces NMDA receptor-dependent synaptic plasticity in cortical networks. 2026. https://doi.org/10.64898/2026.06.17.732958
Paper [11] demonstrates that LTP-patterned electromagnetic stimulation induces NMDA-dependent synaptic plasticity in cortical networks.
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