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the claim

Membrane potential varies between intracellular membranes and the plasma membrane

the verdict
SUPPORTED
the evidence backs this
Recorded sources
3 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Electrical potentials across lipid bilayers exist not only at the plasma membrane but also vary across various intracellular and organellar membranes.

The analysis

Multiple papers (e.g., [3], [0], [2]) directly discuss the presence of distinct membrane potentials across intracellular structures (such as mitochondria and the endoplasmic reticulum) compared to each other or the plasma membrane, supporting the claim.

Evidence for · 3
Detection of the Mitochondrial Membrane Potential by the Cationic Dye JC-1 in L1210 Cells with Massive Overexpression of the Plasma Membrane ABCB1 Drug Transporter
Recorded source metadata

Katarína Elefantová, B. Lakatoš, J. Kubíčková, Z. Sulová, A. Breier. Detection of the Mitochondrial Membrane Potential by the Cationic Dye JC-1 in L1210 Cells with Massive Overexpression of the Plasma Membrane ABCB1 Drug Transporter. 2018. https://doi.org/10.3390/ijms19071985

Paper [0] discusses mitochondrial membrane potential specifically in comparison to the plasma membrane ABCB1 transporter context.

See more details
More for · 2
MICU1 controls spatial membrane potential gradients and guides Ca2+ fluxes within mitochondrial substructures
Recorded source metadata

B. Gottschalk, Zhanat Koshenov, Markus Waldeck-Weiermair, S. Radulović, Furkan E. Oflaz, Martin Hirtl, Olaf A. Bachkoenig, G. Leitinger, R. Malli, W. F. Graier. MICU1 controls spatial membrane potential gradients and guides Ca2+ fluxes within mitochondrial substructures. 2022. https://doi.org/10.1038/s42003-022-03606-3

Paper [2] examines spatial membrane potential gradients between mitochondrial substructures.

Bioorthogonal, fluorogenic targeting of voltage-sensitive fluorophores for visualizing membrane potential dynamics in cellular organelles
Recorded source metadata

Pavel E Z Klier, A. Gest, Julia G. Martin, Ryan Roo, Marisol X. Navarro, L. Lesiak, Parker E Deal, N. Dadina, Jonathan Tyson, A. Schepartz, Evan W. Miller. Bioorthogonal, fluorogenic targeting of voltage-sensitive fluorophores for visualizing membrane potential dynamics in cellular organelles. 2022. https://doi.org/10.1021/jacs.2c02664

Paper [3] contrasts plasma membrane voltage with the membrane potentials found in organellar bilayers such as mitochondria, lysosomes, and the endoplasmic reticulum.

The paper trail · every fact has a biography
first checked01 Aug 2026
judged → SUPPORTED · 8901 Aug 2026
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