Hashimoto thyroiditis leads to severe psychological problems and behavior changes

I. Kamyshna, L. Pavlovych, I. Pankiv, V. Pankiv, V. Maslyanko, N. Bytsko, A. Kamyshnyi. The complex influence of the combination of the BDNF (rs6265), VDR (rs2228570), and NMDA (rs4880213) genotypes on the development of cognitive disorders in patients with autoimmune thyroiditis and hypothyroidism. 2023. https://doi.org/10.22141/2224-0721.19.1.2023.1235

Shows that specific gene variant combinations significantly increase the risk of cognitive disorders in patients with autoimmune thyroiditis and hypothyroidism.

Ma S, Yu P, Chen Q, Alimujiang M, Muhanhali D, Zhang L, Zhao J, Sun X, Ling Y. A cross-sectional study on the lifestyle of patients with Hashimoto's thyroiditis.. 2026. https://doi.org/10.1186/s12902-026-02296-w

Demonstrates that Hashimoto's thyroiditis patients exhibit significantly higher anxiety, depression scores, and poorer sleep quality compared to controls.

Chakraborty A, Kumar R. Effect of Yoga Practices on Hashimoto's Thyroiditis: A Case Report.. 2026. https://doi.org/10.17761/2025-d-24-00054

Notes that Hashimoto's thyroiditis is commonly associated with depression and reports significant reductions in depression and anxiety following integrative management.

Macarenco MM, Opariuc-Dan C, Georgescu T, Căciuloiu L. Psychological and immunological benefits of eye movement desensitization and reprocessing in hashimoto thyroiditis: Preliminary findings from a randomized controlled trial.. 2026. https://doi.org/10.1016/j.psyneuen.2025.107695

Examines psychological distress and trauma in Hashimoto's thyroiditis, noting improvements in depression, anxiety, stress, and dissociation following targeted psychological intervention.

Zhai Q, Gong W, Shen A, Wang Y, Zou H, Huang Y, Shi K, Zhao S, Yan R, Yao Z, Lu Q, Wu J. Cortical structural alterations and thyroid autoantibodies underlying anxiety in major depressive disorder with comorbid Hashimoto's thyroiditis.. 2026. https://doi.org/10.1016/j.pnpbp.2026.111613

Finds that Hashimoto's thyroiditis comorbid with major depressive disorder presents with more severe anxiety linked to thyroid autoantibody levels and cortical alterations.

Tunç S, Altuntaş ŞL, Atmaca M. The effect of photobiomodulation therapy on fatigue and behavioural status in patients with Hashimoto's thyroiditis.. 2026. https://doi.org/10.1007/s10103-026-04864-x

Reports that patients with Hashimoto's thyroiditis experience deterioration in psychological and general well-being alongside fatigue.