Variants on the PolyT sequence have specific functional meanings in gene expression
Variants within polyT and related homopolymer tract sequences possess clear functional roles in regulating transcription termination, promoter strength, and gene expression.
The retrieved literature robustly confirms that variations in polyT and closely related sequence repeats (such as promoter-region polyT tracks or termination signals) have distinct, specific functional consequences on transcription termination and gene expression. Multiple papers (e.g., [0], [3], [8]) directly support this relationship with empirical evidence.
Teng G, Zhang M, Fu Y, Yang X, Kang Y, Qin Q, Jin Y, Huang M, Xu Y. Adaptive attenuation of virulence in hypervirulent carbapenem-resistant <i>Klebsiella pneumoniae</i>.. 2024. https://doi.org/10.1128/msystems.01363-23
Variations in polyT and related repeat promoter sequences (such as P11T and P12T) directly control promoter activity and virulence gene expression in Klebsiella pneumoniae.
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Cackett G, Sýkora M, Portugal R, Dulson C, Dixon L, Werner F. Transcription termination and readthrough in African swine fever virus.. 2024. https://doi.org/10.3389/fimmu.2024.1350267
PolyT stretches serve as universal transcription termination signals that dictate transcript processing and gene expression regulation in viral systems.
Puppala AK, Nielsen AC, Regan M, Mancinelli GE, De Pooter RF, Arnovitz S, Harding C, McGregor M, Balanis NG, Clarke R, Merrill BJ. Programmable multistep CRISPR gene activation via control of RNA polymerase III termination.. 2025. https://doi.org/10.1126/sciadv.adt1532
The targeted manipulation and removal of RNA polymerase III polyT termination sequences function as a switch to program gene activation cascades.
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