Dry skin causes itching through specific neurological and inflammatory pathways.
Dry skin triggers itching through well-documented neuro-immune interactions, involving keratinocyte dysfunction, inflammatory mediators, and activation of sensory nerve pathways.
The retrieved papers consistently support the claim that dry skin (xerosis) and associated cutaneous conditions induce pruritus through specific inflammatory and neurological pathways involving neurocutaneous crosstalk, pruritogens, and sensory nerve activation.
Criado PR, Jardim Criado RF, Ianhez M, Miot HA. Chronic pruritus: a narrative review.. 2025. https://doi.org/10.1016/j.abd.2024.09.008
Reviews how chronic pruritus involves neurological and inflammatory pathways including nerve fibers and immune cells.
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Marino M, Rosset F, Nervo A, Piovesan A, Pala V, Vaccaro E, Mastorino L, Calogero AE, Arvat E. Cutaneous Adverse Events of Tyrosine Kinase Inhibitors in Endocrine Tumors: Clinical Features, Mechanisms, and Management Strategies.. 2025. https://doi.org/10.3390/biomedicines13123044
Notes that conditions like xerosis (dry skin) cause skin reactions driven by keratinocyte dysfunction, inflammation, and neurovascular changes.
Li Z, Yu N, Feng S, Wang X, Chu YX, Liu X. The neuro-immune insights of itch: peripheral mechanisms and central glial contributions.. 2026. https://doi.org/10.1186/s11658-025-00834-3
Explores how inflammatory and neurological processes drive itch signaling through interactions between sensory neurons and immune mediators.
Sun S, Lin J, Wang X, Liu T, Zhou G, Kang P. Emerging roles of lipocalin-2-mediated neuroimmune interactions in chronic pain and itch.. 2026. https://doi.org/10.3389/fphar.2026.1799602
Details how factors involved in dry skin and dermatitis modulate pruritus-related neurons via inflammatory pathways like the IL-6/STAT3 axis.
Wang F, An X, Fan D, Shang J. The interplay between epidermal cells and the cutaneous sensory nervous: a systematic review.. 2026. https://doi.org/10.3389/fimmu.2026.1809838
Examines the bidirectional regulatory crosstalk between epidermal cells and the cutaneous sensory nervous system.
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