E. coli shifts feedstocks within a measurable timeframe
Studies on E. coli demonstrate that the bacterium dynamically shifts its metabolic pathways and substrate utilization profiles within measurable timeframes in response to environmental changes.
The claim is specific, empirical, and testable. Multiple retrieved papers directly discuss or model metabolic shifts, adaptation rates, and temporal metabolic rewiring in E. coli within measurable timeframes (e.g., dynamic flux balance modeling, real-time substrate uptake dynamics, and phase-driven enzyme synchronization). There are no papers refuting the claim.
Dukovski I, Golden L, Zhang J, Osborne M, Segrè D, Korolev KS. Biophysical metabolic modeling of complex bacterial colony morphology.. 2025. https://doi.org/10.1016/j.cels.2025.101352
Paper 2 demonstrates metabolic modeling that captures how E. coli colonies dynamically adjust their metabolic reactions as a function of the surrounding environment over time.
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Li H, Wu Y, Qin D, Xie J, Huang W, Chen R, Liu H, Wang Y, Zhao D. Phase-driven rewiring in Escherichia coli enhances coenzyme Q10 biosynthesis via temporal and energetic coordination.. 2025. https://doi.org/10.1007/s00253-025-13619-7
Paper 7 describes phase-driven temporal coordination and dynamic metabolic rewiring in E. coli within controlled timeframes.
Ibaceta M, Neudert MR, Marques N, Kahrer S, Herwig C, Steinboeck A. The dynamic growth of bacterial cultures: real-time Bayesian estimation of substrate uptake rates in fed-batch fermentations of E. coli.. 2026. https://doi.org/10.1007/s00449-025-03251-0
Paper 10 explicitly models the substrate uptake dynamics and adaptation rate of E. coli during fed-batch fermentations to estimate metabolic parameter shifts in real time.
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