Abnormal thyroid function is linked to obesity
Abnormal thyroid function is closely linked to obesity and alterations in energy homeostasis, with multiple studies demonstrating significant associations between abnormal thyroid hormone levels, sensitivity indicators, and increased adiposity.
The provided literature consistently supports the link between abnormal thyroid function and obesity, showing correlations between altered thyroid hormone levels, sensitivity indices, and metabolic or body composition parameters. Papers [0], [1], [2], [4], and [6] all report various facets of this relationship, while the remaining papers focus on distinct topics such as bone density, menstrual irregularities, sleep quality, or thyroid antibodies without refuting the claim.
Cicatiello AG, Miro C, Sagliocchi S, Nappi A, Dentice M. Thyroid hormones and metabolic flexibility: tissue-specific control of energy homeostasis.. 2026. https://doi.org/10.3389/fphys.2026.1882438
Reviews tissue-specific mechanisms of thyroid hormones in energy homeostasis and their alterations in obesity.
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Hernandez A, Celi FS. Diet's rapid effects on the thyroid gland challenge unidirectional assumptions about hypothyroidism and energy balance.. 2026. https://doi.org/10.1172/jci205029
Demonstrates that overnutrition can lead to functional impairment in the thyroid gland and altered hormone levels linked to energy balance.
Alrajhi DS, Ai-Musharaf S, Mazi TA, Aldhwayan M, Abolmeaty M, Aljuraiban GS. Body composition indices align with thyroid variation in euthyroid Saudi adults: A cross-sectional study.. 2026. https://doi.org/10.1177/03000605261444581
Finds that body composition indices, including adiposity and waist circumference, align with variations in thyroid hormones among adults.
Zhang Y, Bao C, Liu L, Liu R, Wang X, Guo X, Li C. Association Between Thyroid Hormone Sensitivity Indicators and Controlled Attenuation Parameter (CAP) Values in Euthyroid Adults with Overweight/Obesity.. 2026. https://doi.org/10.2147/dmso.s564396
Shows that thyroid hormone sensitivity indicators are significantly correlated with hepatic steatosis in individuals with overweight or obesity.
Ren XK, Fu Y, Zhu SG, Li RZ, Xia YZ. Association between cardiometabolic index and primary hypothyroidism: A cross-sectional study based the NHANES (2007-2012).. 2026. https://doi.org/10.1097/md.0000000000049270
Identifies a strong positive association between increased cardiometabolic index scores and primary hypothyroidism.
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