Blocking all human sweat glands causes fatal hyperthermia
Blocking all human sweat glands prevents evaporative cooling, which is the primary mechanism for human heat dissipation and can lead to fatal hyperthermia under heat stress.
The retrieved literature confirms that eccrine sweating and evaporative cooling are essential mechanisms for human thermoregulation, and conditions like anhidrosis (absence of sweating) directly lead to dangerous or fatal hyperthermia (heat stroke). Thus, the claim is well-supported by physiological principles.
Cramer MN, Gagnon D, Laitano O, Crandall CG. Human temperature regulation under heat stress in health, disease, and injury.. 2022. https://doi.org/10.1152/physrev.00047.2021
Paper [3] highlights that temperature regulation is a critical homeostatic system relying on heat dissipation mechanisms like sweating to maintain deep body temperature.
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Craig G. Crandall. Mechanisms and controllers of eccrine sweating in humans. 2009. https://doi.org/10.2741/s94
Paper [4] notes that evaporative heat loss via sweat secretion is the primary mechanism of heat dissipation in humans, particularly when ambient temperatures are high.
Chelsea S. Navarro, Douglas J. Casa, Luke N. Belval, Nathaniel S. Nye. Exertional Heat Stroke. 2017. https://doi.org/10.1249/jsr.0000000000000403
Paper [7] identifies anhidrosis (lack of sweating) as a major intrinsic risk factor for exertional heat stroke and life-threatening hyperthermia.
Williams ML. Global warming, heat-related illnesses, and the dermatologist.. 2021. https://doi.org/10.1016/j.ijwd.2020.08.007
Paper [10] explains that eccrine sweating and subsequent evaporation are vital for cooling, and disorders of eccrine function severely impair the skin's capacity to thermoregulate.
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