RISUG provides a simple and effective form of male birth control
Clinical and experimental studies indicate that RISUG is a safe, effective, and potentially reversible form of non-hormonal male contraception.
The retrieved papers consistently support the claim that RISUG is an effective and safe male contraceptive with demonstrated reversibility across animal models and human clinical trials. There are no papers in the provided set that refute this claim.
Abdul S. Ansari, Mubarik Hussain, Sadi Rehan Khan, Ayesha Badar, Barkha Khilwani, Nirmal Kumar Lohiya. Studies on biochemical, oxidative and genotoxicity alterations following vas blockage with reversible inhibition of sperm under guidance and reversal in rats. 2022. https://doi.org/10.4103/ijp.ijp_557_20
Demonstrates that RISUG vas occlusion and its reversal procedures in rats do not cause significant toxicological manifestations or oxidative stress.
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Abdul Salam Ansari, Kiran Sevliya, Ayesha Badar, Nirmal Kumar Lohiya. Reversible inhibition of sperm under guidance as an intratubular and reversible contraception in female rats: An experimental study. 2021. https://doi.org/10.18502/ijrm.v19i1.8179
Shows that RISUG provides effective and reversible tubular occlusion in animal experimental models.
N K Lohiya, I Alam, M Hussain, S R Khan, A S Ansari. RISUG: an intravasal injectable male contraceptive.. 2014. https://pubmed.ncbi.nlm.nih.gov/25673546/
Highlights RISUG as a promising long-term, single-injection male contraceptive with demonstrated reversibility.
S P Chaki, H C Das, M M Misro. A short-term evaluation of semen and accessory sex gland function in phase III trial subjects receiving intravasal contraceptive RISUG.. 2003. https://doi.org/10.1016/s0010-7824(02)00442-0
Confirms that RISUG effectively acts as an occluding agent in the vas deferens, successfully preventing pregnancy in human subjects.
Radhey Shyam Sharma, Ajit Kumar Mathur, Rajeev Singh, Hem Chandra Das, Gulshan Jeet Singh, Devinder Pal Singh Toor, Sujoy Kumar Guha. Safety & efficacy of an intravasal, one-time injectable & non-hormonal male contraceptive (RISUG): A clinical experience.. 2019. https://doi.org/10.4103/ijmr.IJMR_635_18
Clinical trial data in human volunteers shows that RISUG is a safe procedure with high sustained contraceptive efficacy and minimal adverse effects.
Mikołaj Frankiewicz, Wojciech Połom, Marcin Matuszewski. Can the evolution of male contraception lead to a revolution? Review of the current state of knowledge.. 2018. https://doi.org/10.5173/ceju.2017.1450
Evaluates non-hormonal male contraceptives and recognizes RISUG as a very promising option close to market introduction.
Barkha Khilwani, Ayesha Badar, Abdul S Ansari, Nirmal K Lohiya. RISUG® as a male contraceptive: journey from bench to bedside.. 2020. https://doi.org/10.1186/s12610-020-0099-1
Reviews the developmental journey of RISUG as a safe, effective, and long-term male contraceptive alternative to vasectomy.
A S Ansari, M Hussain, S R Khan, N K Lohiya. Relative suitability of DMSO and NaHCO3 for reversal of RISUG® induced long-term contraception.. 2016. https://doi.org/10.1111/andr.12155
Demonstrates that RISUG induces long-term contraception that can be successfully reversed using DMSO or NaHCO3.
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