Bipolar disorder is linked to dysfunction in the brain's emotional and social circuits.
Extensive neuroimaging and clinical research demonstrates that bipolar disorder is closely associated with functional and structural dysfunctions within the brain's emotional and social processing circuits.
The retrieved papers consistently support the claim that bipolar disorder involves significant alterations and dysfunctions within emotion regulation, cortico-limbic, and social-cognitive brain circuits.
S. Njau, J. Townsend, B. Wade, G. Hellemann, S. Bookheimer, K. Narr, J. Brooks. Neural Subtypes of Euthymic Bipolar I Disorder Characterized by Emotion Regulation Circuitry.. 2020. https://doi.org/10.1016/j.bpsc.2020.02.011
This study demonstrates that euthymic bipolar I disorder is characterized by distinct neural subtypes involving emotion regulation circuitry.
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M. Bertocci, J. Bergman, J. Santos, S. Iyengar, L. Bonar, M. Gill, Halimah Abdul-Waalee, G. Bebko, R. Stiffler, J. Lockovich, Haris A. Aslam, C. Ladouceur, J. Merranko, R. Diler, B. Birmaher, A. Versace, M. Phillips. Emotional regulation neural circuitry abnormalities in adult bipolar disorder: dissociating effects of long-term depression history from relationships with present symptoms. 2020. https://doi.org/10.1038/s41398-020-01048-1
The research highlights how abnormalities in neural networks related to emotion processing and social cognition underpin bipolar disorder symptoms.
Lori L. Altshuler, Jennifer D. Townsend. Functional Brain Imaging in Bipolar Disorder. 2012. https://doi.org/10.1093/med/9780199797608.003.0032
Findings show that frontolimbic abnormalities and diminished subcortical-limbic modulation act as substrates for acute mood episodes in bipolar disorder.
Ogłodek EA, Vober J, Hýža M. Molecular and Neuroimaging Correlates of Bipolar Disorder: Linking Inflammation, Mitochondria, and Brain Circuitry.. 2026. https://doi.org/10.3390/ijms27031478
This paper links mitochondrial dysfunction and neuroinflammation to structural and functional alterations in cortico-limbic emotion-regulating networks in bipolar disorder.
Gupta R, Jha NK, Kumar N, Nagraik R, Ravi K. From synapse to system: mechanistic pathways of neural signaling dysfunction in psychiatric disorders.. 2026. https://doi.org/10.3389/fcell.2026.1762930
The study notes that bipolar disorder involves widespread network dysconnectivity and fronto-limbic system abnormalities impacting emotional signaling.
Wong E, Loconte R, Terigi F, Giani E, Bucci M, De Rossi MM, Coraci D, Milone A, Masi G, Cecchetti L, Sesso G. Neurofunctional Correlates of Emotional Dysregulation: Systematic Review and ALE Meta-Analysis.. 2026. https://doi.org/10.1002/brb3.71376
This meta-analysis identifies shared neural dysfunctions in emotional reactivity and cognitive regulation regions among conditions including bipolar disorder.
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