Certain antibiotics cause ototoxicity by damaging inner ear sensory cells
Multiple peer-reviewed studies establish that certain classes of antibiotics, such as aminoglycosides and glycopeptides, cause ototoxicity by damaging and destroying inner ear sensory hair cells.
The retrieved literature robustly confirms that certain antibiotics (such as aminoglycosides and teicoplanin) induce ototoxicity by targeting and damaging sensory hair cells in the inner ear. Papers [0], [1], [2], [3], [5], and [8] directly support this statement with experimental and review data. No papers refute the claim.
Debara L. Tucci, Edwin W Rubel. Physiologic Status of Regenerated Hair Cells in the Avian Inner Ear following Aminoglycoside Ototoxicity. 1990. https://doi.org/10.1177/019459989010300317
Demonstrates that the aminoglycoside antibiotic gentamicin causes hearing loss and ototoxicity via inner ear hair cell damage.
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Steyger PS. Mechanisms of Aminoglycoside- and Cisplatin-Induced Ototoxicity.. 2021. https://doi.org/10.1044/2021_aja-21-00006
Reviews acquired hearing loss from hospital-prescribed medications, highlighting aminoglycoside antibiotics as a major cause of ototoxicity.
Steyger PS. Mechanisms of Ototoxicity and Otoprotection.. 2021. https://doi.org/10.1016/j.otc.2021.08.007
Discusses fundamental mechanisms of ototoxicity by clinically relevant medications, specifically citing aminoglycoside antibiotics.
Rivetti S, Romano A, Mastrangelo S, Attinà G, Maurizi P, Ruggiero A. Aminoglycosides-Related Ototoxicity: Mechanisms, Risk Factors, and Prevention in Pediatric Patients.. 2023. https://doi.org/10.3390/ph16101353
Notes that aminoglycosides cause permanent ototoxicity through toxic side effects acting on inner ear cells.
Jin Guo, Honglin Mei, Yanping Zhang, Chenhao Che, Luo Guo, Yunzhong Zhang, Huawei Li, Shan Sun. Glutamate-aspartate transporter dysfunction enhances aminoglycoside-induced cochlear hair cell death via NMDA receptor activation.. 2023. https://doi.org/10.1016/j.neuint.2023.105587
Evaluates gentamicin cytotoxicity and its reduction via feeding protocols, confirming aminoglycoside damage to cochlear and vestibular sensory hair cells.
Qiongmin Zhang, Zhi Yao, Fang Chen, Xue Wang, Man Wang, Junze Lu, Yu Meng, Lei Xu, Yuechen Han, Wenwen Liu, Haibo Wang. TIGAR Protects Cochlear Hair Cells against Teicoplanin-Induced Damage. 2023. https://doi.org/10.1007/s12035-023-03309-8
Shows that the antibiotic teicoplanin causes dose-dependent cell death in cochlear hair cells.
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