Humans do not produce rennin as adults.

the verdict

SUPPORTED

the evidence backs this

Recorded sources

3 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Scientific evidence confirms that the production of rennin (chymosin) is specific to the neonatal and infant stages of development, shifting to adult-type pepsinogens as animals mature.

The analysis

The provided literature consistently indicates that chymosin (rennin) and its zymogen precursor prochymosin are infant/neonatal-specific gastric enzymes whose gene expression and cellular presence decline sharply postnatally, being replaced by adult pepsinogens.

Evidence for · 3

Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development.

Recorded source metadata

T Kageyama. Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development.. 2002. https://doi.org/10.1007/s00018-002-8423-9

States that prochymosin is the main form in the fetus/infant and switches to adult-type pepsinogens during postnatal development.

Source citation format

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More for · 2

Molecular cloning of neonate/infant-specific pepsinogens from rat stomach mucosa and their expressional change during development.

Recorded source metadata

T Kageyama, M Ichinose, S Tsukada-Kato, M Omata, Y Narita, A Moriyama, S Yonezawa. Molecular cloning of neonate/infant-specific pepsinogens from rat stomach mucosa and their expressional change during development.. 2000. https://doi.org/10.1006/bbrc.1999.2047

Confirms that prochymosin genes are expressed only at neonatal/infant stages.

Source citation format

Immunohistochemical study of the ontogeny of prochymosin--and pepsinogen-producing cells in the abomasum of sheep.

Recorded source metadata

N Kitamura, A Tanimoto, E Hondo, A Andrén, D F Cottrell, M Sasaki, J Yamada. Immunohistochemical study of the ontogeny of prochymosin--and pepsinogen-producing cells in the abomasum of sheep.. 2001. https://doi.org/10.1046/j.1439-0264.2001.00326.x

Shows that prochymosin-immunoreactive cells are significantly reduced throughout postnatal growth and are only sparsely found in adults.

Source citation format

The paper trail · every fact has a biography

first checked01 Aug 2026

judged → SUPPORTED · 7501 Aug 2026

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