Handedness is determined by a dominant genetic inheritance pattern
Although twin and family studies suggest that handedness has a heritable component, large-scale genome-wide association studies have largely failed to validate simple dominant genetic inheritance patterns, pointing instead to a complex multifactorial etiology.
The claim specifies that handedness is determined by a 'dominant genetic inheritance pattern'. While older candidate gene studies and twin models point to genetic influence, high-powered modern genomic studies (like the UK Biobank GWAS) contradict the idea of simple or major single-gene dominant models, showing that previous candidate associations were likely false positives and favoring a complex, multifactorial origin. Therefore, the strict claim of a dominant genetic inheritance pattern is contested by modern large-scale evidence.
Amar J S Klar. A 1927 Study Supports a Current Genetic Model for Inheritance of Human Scalp Hair-Whorl Orientation and Hand-Use Preference Traits. 2005. https://doi.org/10.1534/genetics.104.039990
Supports a genetic model for handedness inheritance.
Carolien G F de Kovel, Clyde Francks. The molecular genetics of hand preference revisited.. 2019. https://doi.org/10.1038/s41598-019-42515-0
Fails to find evidence supporting previously suggested genetic variants for hand preference in a large cohort, suggesting earlier findings were likely false positives.
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Pattarawat Chormai, Yi Pu, Haoyu Hu, Simon E Fisher, Clyde Francks, Xiang-Zhen Kong. Machine learning of large-scale multimodal brain imaging data reveals neural correlates of hand preference.. 2022. https://doi.org/10.1016/j.neuroimage.2022.119534
Finds significant heritability for human handedness and its neuroimaging correlates.
William D Hopkins, Lisa Reamer, Mary Catherine Mareno, Steven J Schapiro. Genetic basis in motor skill and hand preference for tool use in chimpanzees (Pan troglodytes).. 2015. https://doi.org/10.1098/rspb.2014.1223
Indicates that handedness is significantly heritable in chimpanzees as well.
Alexandre Jehan Marcori, Victor Hugo Alves Okazaki. A historical, systematic review of handedness origins.. 2020. https://doi.org/10.1080/1357650X.2019.1614597
Concludes that multifactorial, developmental approaches involving both genetic and environmental factors are the most up-to-date view of handedness formation.
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